MP07-Bases Fisiopatología y Terapéutica Médica

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Grupo de investigación dedicado a profundizar en el conocimiento de las enfermedades autoinmunes sistémicas desde el punto de vista epidemiológico, clínico, genético y de inmunología básica. Además, trabaja en el estudio de los factores de riesgo asociados con el desarrollo de osteoporosis esteroidea, así como de su prevención y tratamiento.

Líneas de investigación

Nutrición y Enfermedades Autoinmunes Sistémicas
Genética de Enfermedades Autoinmunes Sistémicas
Osteoporosis corticoide
Epidemiología de Enfermedades Autoinmunes Sistémicas
Aspectos clínicos y complicaciones de las Enfermedades Autoinmunes

Palabras clave

Enfermedades Autoinmunes, Lupus, Esclerodermia, Vasculitis Sistémicas, Uveitis, Osteoporosis Y Glucocorticoídes.

SARA DEL OLMO ROMERO

MARIA DEL ROCIO GIL GUTIERREZ

ORCID

MARTA GARCIA MORALES

JAVIER DE LA HERA FERNANDEZ

ORCID

MARIALBERT ACOSTA HERRERA

ORCID

ELIO GABRIEL CARMONA RUBIO

JOSE LUIS CALLEJAS RUBIO

Díaz-Villamarín, X; Fernández-Varón, E; Romero, MCR; Callejas-Rubio, JL; Cabeza-Barrera, J; Rodríguez-Nogales, A; Gálvez, J; Morón, R

Azathioprine dose tailoring based on pharmacogenetic information: Insights of clinical implementation

BIOMEDICINE & PHARMACOTHERAPY, 2023;

FI:7,5; Q1

Rodriguez-Martin, I; Villanueva-Martin, G; Guillen-Del-Castillo, A; Ortego-Centeno, N; Callejas, JL; Simeón-Aznar, CP; Martin, J; Acosta-Herrera, M

Contribution of Telomere Length to Systemic Sclerosis Onset: A Mendelian Randomization Study

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023;

FI:5,6; Q1

Casas-Barragán, A; García-Ríos, MC; Rus, A; Tapia-Haro, RM; Correa-Rodríguez, M; Aguilar-Ferrándiz, ME

Associations among serum VEGF and CGRP levels with the peripheral vascular blood flow of the skin of the hands in women with Fibromyalgia

JOURNAL OF THERMAL BIOLOGY, 2023;

FI:2,7; Q2

Rus, A; López-Sánchez, JA; García-Ríos, MC; Tapia-Haro, RM; Casas-Barragán, A; Correa-Rodríguez, M; Aguilar-Ferrándiz, ME

Calcitonin Gene-Related Peptide, Vascular Endothelial Growth Factor, and Clinical Manifestations in Women With Fibromyalgia

NURSING RESEARCH, 2023;

FI:2,5; Q2

Correa-Rodríguez, M; Rueda-Medina, B; Callejas-Rubio, JL; Ríos-Fernández, R; Gil-Gutiérrez, R; Ortego-Centeno, N

Adherence to antimalarials and glucocorticoids treatment and its association with self-reported disease activity in systemic lupus erythematosus patients

LUPUS, 2023;

FI:2,6; Q3

Fernandez-Aparicio, A; Correa-Rodriguez, M; Castellano, JM; Schmidt-RioValle, J; Perona, JS; Gonzalez-Jimenez, E

Potential Molecular Targets of Oleanolic Acid in Insulin Resistance and Underlying Oxidative Stress: A Systematic Review

ANTIOXIDANTS, 2022;

FI:7,675; D1

Carbonell, C; Marcos, M; Guillen-Del-Castillo, A; Rubio-Rivas, M; Argibay, A; Marin-Ballve, A; Rodriguez-Pinto, I; Balda-Masmiquel, M; Callejas-Moraga, E; Colunga, D; Saez-Comet, L; Gonzalez-Echavarri, C; Ortego-Centeno, N; Mari-Alfonso, B; Vargas-Hitos, JA; Todoli-Parra, JA; Trapiella, L; Herranz-Marin, MT; Freire, M; Castro-Salomo, A; Perales-Fraile, I; Madronero-Vuelta, AB; Sanchez-Garcia, ME; Ruiz-Munoz, M; Gonzalez-Garcia, A; Sanchez-Redondo, J; De-la-Red-Bellvis, G; Fernandez-Luque, A; Muela-Molinero, A; Lledo, GM; Tolosa-Vilella, C; Fonollosa-Pla, V; Chamorro, AJ; Simeon-Aznar, CP

Standardized incidence ratios and risk factors for cancer in patients with systemic sclerosis: Data from the Spanish Scleroderma Registry (RESCLE)

AUTOIMMUNITY REVIEWS, 2022;

FI:17,39; D1

Ramirez-Velez, R; Garcia-Hermoso, A; Correa-Rodriguez, M; Izquierdo, M

Defining values for controlled attenuation parameter and liver stiffness in youth without liver disease

PEDIATRIC RESEARCH, 2022;

FI:3,953; Q1

Ramirez-Velez, R; Garcia-Hermoso, A; Correa-Rodriguez, M; Fernandez-Irigoyen, J; Palomino-Echeverria, S; Santamaria, E; Correa-Bautista, JE; Gonzalez-Ruiz, K; Izquierdo, M

Effects of Different Doses of Exercise on Inflammation Markers Among Adolescents With Overweight/Obesity: HEPAFIT Study

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2022;

FI:6,134; Q1

Gonzalez-Ruiz, K; Correa-Bautista, JE; Izquierdo, M; Garcia-Hermoso, A; Martinez-Vizcaino, V; Lobelo, F; Gonzalez-Jimenez, E; Schmidt-RioValle, J; Correa-Rodriguez, M; Fernandez-Irigoyen, J; Palomino-Echeverria, S; Santamaria, E; Ramirez-Velez, R

Exercise dose on hepatic fat and cardiovascular health in adolescents with excess of adiposity.

PEDIATRIC OBESITY, 2022;

FI:3,91; Q1

Simon, Q; Grasseau, A; Boudigou, M; Le Pottier, L; Bettachioli, E; Cornec, D; Rouviere, B; Jamin, C; Le Lann, L; Borghi, MO; Aguilar-Quesada, R; Renaudineau, Y; Alarcon-Riquelme, ME; Pers, JO; Hillion, S

A Proinflammatory Cytokine Network Profile in Th1/Type 1 Effector B Cells Delineates a Common Group of Patients in Four Systemic Autoimmune Diseases

ARTHRITIS & RHEUMATOLOGY, 2021;

FI:10,995; D1

Rueda-Medina, B; Gomez-Urquiza, JL; Molina-Rivas, E; Tapia-Haro, R; Aguilar-Ferrandiz, ME; Correa-Rodriguez, M

A Combination of Self-debriefing and Instructor-led Debriefing Improves Team Effectiveness in Health Science Students….

NURSE EDUCATOR, 2021;

FI:2,082; Q2

Rueda-Medina, B; Gomez-Urquiza, JL; Molina-Rivas, E; Tapia-Haro, R; Aguilar-Ferrandiz, ME; Correa-Rodriguez, M

A Combination of Self-debriefing and Instructor-led Debriefing Improves Team Effectiveness in Health Science Students

NURSE EDUCATOR, 2021;

FI:2,082; Q2

Ramirez-Velez, R; Garcia-Hermoso, A; Correa-Rodriguez, M; Lobelo, F; Gonzalez-Ruiz, K; Izquierdo, M

Abdominal aortic calcification is associated with decline in handgrip strength in the US adult population >40 years of age.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 2021;

FI:4,222; Q2

Ramirez-Velez, R; Garcia-Hermoso, A; Correa-Rodriguez, M; Lobelo, F; Gonzalez-Ruiz, K; Izquierdo, M

Abdominal aortic calcification is associated with decline in handgrip strength in the US adult population >40 years of age

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 2021;

FI:4,222; Q2

Gonzalez-Serna, D; Ochoa, E; Lopez-Isac, E; Julia, A; Degenhardt, F; Ortego-Centeno, N; Radstake, TRDJ; Franke, A; Marsal, S; Mayes, MD; Martin, J; Marquez, A

A cross-disease meta-GWAS identifies four new susceptibility loci shared between systemic sclerosis and Crohn’s disease

SCIENTIFIC REPORTS, 2020;

FI:3,998; Q1

Atencio-Osorio, MA; Carrillo-Arango, HA; Correa-Rodriguez, M; Ochoa-Munoz, AF; Ramirez-Velez, R

Adherence to the Mediterranean Diet in College Students: Evaluation of Psychometric Properties of the KIDMED Questionnaire

NUTRIENTS, 2020;

FI:4,546; Q1

Rueda-Medina, B; Gomez-Urquiza, JL; Tapia-Haro, R; Casas-Barragan, A; Aguilar-Ferrandiz, ME; Correa-Rodriguez, M

Assessing health science students’ health literacy and its association with health behaviours

HEALTH & SOCIAL CARE IN THE COMMUNITY, 2020;

FI:2,05; Q1

Ramirez-Velez, R; Perez-Sousa, MA; Cano-Gutierrez, CA; Izquierdo, M; Garcia-Hermoso, A; Correa-Rodriguez, M

Association Between Ideal Cardiovascular Health Score and Relative Handgrip Strength of Community-Dwelling Older Adults in Colombia

JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION, 2020;

FI:4,367; Q1

Alvarez-Cienfuegos, A; Cantero-Nieto, L; Garcia-Gomez, JA; Sabio, JM; Gonzalez-Gay, MA; Ortego-Centeno, N

Association between homocysteine levels and arterial stiffness in women with systemic sclerosis

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2020;

FI:3,319; Q2

Acosta-Herrera, M; Kerick, M; Gonzalez-Serna, D; Wijmenga, C; Franke, A; Gregersen, PK; Padyukov, L; Worthington, J; Vyse, TJ; Alarcon-Riquelme, ME; Mayes, MD; Martin, J; Miller, FW; Chen, W; O'Hanlon, TP; Cooper, RG; Vencovsky, J; Rider, LG; Danko, K; Wedderburn, LR; Lundberg, IE; Pachman, LM; Reed, AM; Ytterberg, SR; Selva-O'Callaghan, A; Radstake, TR; Isenberg, DA; Chinoy, H; Ollier, WER; Scheet, P; Peng, B; Lee, A; Lamb, JA; Amos, CI; Denton, C; Hilton-Jones, D; Plotz, PH; Varsani, H; Radstake, TRDJ; Gorlova, O; Rueda, B; Martin, JE; Alizadeh, BZ; Palomino-Morales, R; Coenen, MJ; Vonk, MC; Voskuyl, AE; Scheurwegh, AJ; Broen, JC; van Riel, PLCM; van 't Slot, R; Italiaander, A; Ophoff, RA; Riemekasten, G; Hunzelmann, N; Simeon, CP; Ortego-Centeno, N; Gonzalez-Gay, MA; Gonzalez-Escribano, MF; Airo, P; van Laar, J; Herrick, A; Hesselstrand, R; Smith, V; de Keyser, F; Houssiau, F; Chee, MM; Madhok, R; Shiels, P; Westhovens, R; Kreuter, A; Kiener, H; de Baere, E; Witte, T; Klareskog, L; Beretta, L; Scorza, R; Lie, BA; Hoffman-Vold, AM; Carreira, P; Varga, J; Hinchcliff, M; Lee, AT; Ying, J; Han, Y; Weng, SF; Wigley, FM; Hummers, L; Nelson, JL; Agarwal, SK; Assassi, S; Gourh, P; Tan, FK; Koeleman, BPC; Arnett, FC

Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases

ANNALS OF THE RHEUMATIC DISEASES, 2019;

FI:14,299; D1

Atienza-Mateo, B; Martin-Varillas, JL; Calvo-Rio, V; Demetrio-Pablo, R; Beltran, E; Sanchez-Burson, J; Mesquida, M; Adan, A; Hernandez, MV; Hernandez-Garfella, M; Valls-Pascual, E; Martinez-Costa, L; Sellas-Fernandez, A; Cordero-Coma, M; Diaz-Llopis, M; Gallego, R; Garcia-Serrano, JL; Ortego-Centeno, N; Herreras, JM; Fonollosa, A; Garcia-Aparicio, AM; Maiz-Alonso, O; Blanco, A; Torre-Salaberri, I; Fernandez-Espartero, C; Jovani, V; Peiteado, D; Pato, E; Cruz, J; Fernandez-Cid, C; Aurrecoechea, E; Garcia-Arias, M; Castaneda, S; Caracuel-Ruiz, MA; Montilla-Morales, CA; Atanes-Sandoval, A; Francisco, F; Insua, S; Gonzalez-Suarez, S; Sanchez-Andrade, A; Gamero, F; Ferrando, LFL; Romero-Bueno, F; Garcia-Gonzalez, AJ; Gonzalez, RA; Muro, EM; Carrasco-Cubero, C; Olive, A; Prior, A; Vazquez, J; Ruiz-Moreno, O; Jimenez-Zorzo, F; Manero, J; Fernandez, SM; Fernandez-Carballido, C; Rubio-Romero, E; Pages, FA; de Miera, FJTS; Martinez, MG; Diaz-Valle, D; Longo, FJL; Nolla, JM; Alvarez, ER; Martinez, MR; Gonzalez-Lopez, JJ; Rodriguez-Cundin, P; Hernandez, JL; Gonzalez-Gay, MA; Blanco, R

Comparative Study of Infliximab Versus Adalimumab in Refractory Uveitis due to Behcet’s Disease: National Multicenter Study of 177 Cases

ARTHRITIS & RHEUMATOLOGY, 2019;

FI:9,002; D1

Cavagna, L; Trallero-Araguas, E; Meloni, F; Cavazzana, I; Rojas-Serrano, J; Feist, E; Zanframundo, G; Morandi, V; Meyer, A; da Silva, JAP; Costa, CJM; Molberg, O; Andersson, H; Codullo, V; Mosca, M; Barsotti, S; Neri, R; Scire, C; Govoni, M; Furini, F; Lopez-Longo, FJ; Martinez-Barrio, J; Schneider, U; Lorenz, HM; Doria, A; Ghirardello, A; Ortego-Centeno, N; Confalonieri, M; Tomietto, P; Pipitone, N; Cambron, ABR; Canamero, MAB; Voll, RE; Wendel, S; Scarpato, S; Maurier, F; Limonta, M; Colombelli, P; Giannini, M; Geny, B; Arrigoni, E; Bravi, E; Migliorini, P; Mathieu, A; Piga, M; Drott, U; Delbrueck, C; Bauhammer, J; Cagnotto, G; Vancheri, C; Sambataro, G; De Langhe, E; Sainaghi, PP; Monti, C; Berzolari, FG; Romano, M; Bonella, F; Specker, C; Schwarting, A; Blanco, IV; Selmi, C; Ceribelli, A; Nuno, L; Mera-Varela, A; Gomez, NP; Fusaro, E; Parisi, S; Sinigaglia, L; Del Papa, N; Benucci, M; Cimmino, MA; Riccieri, V; Conti, F; Sebastiani, GD; Iuliano, A; Emmi, G; Cammelli, D; Sebastiani, M; Manfredi, A; Bachiller-Corral, J; Giraldo, WAS; Paolazzi, G; Saketkoo, LA; Giorgi, R; Salaffi, F; Cifrian, J; Caporali, R; Locatelli, F; Marchioni, E; Pesci, A; Dei, GL; Pozzi, MR; Claudia, L; Distler, J; Knitza, J; Schett, G; Iannone, F; Fornaro, M; Franceschini, F; Quartuccio, L; Gerli, R; Bartoloni, E; Randone, SB; Zampogna, G; Perez, MIG; Mejia, M; Vicente, E; Triantafyllias, K; Lopez-Mejias, R; Matucci-Cerinic, M; Selva-O'Callaghan, A; Castaneda, S; Montecucco, C; Gonzalez-Gay, MA

Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course

JOURNAL OF CLINICAL MEDICINE, 2019;

FI:5,688; D1

Lopez-Isac, E; Acosta-Herrera, M; Kerick, M; Assassi, S; Satpathy, AT; Granja, J; Mumbach, MR; Beretta, L; Simeon, CP; Carreira, P; Ortego-Centeno, N; Castellvi, I; Bossini-Castillo, L; Carmona, FD; Orozco, G; Hunzelmann, N; Distler, JHW; Franke, A; Lunardi, C; Moroncini, G; Gabrielli, A; de Vries-Bouwstra, J; Wijmenga, C; Koeleman, BPC; Nordin, A; Padyukov, L; Hoffmann-Vold, AM; Lie, B; Rios, R; Callejas, JL; Vargas-Hitos, JA; Garcia-Portales, R; Camps, MT; Fernandez-Nebro, A; Gonzalez-Escribano, MF; Garcia-Hernandez, FJ; Castillo, MJ; Aguirre, MA; Gomez-Gracia, I; Fernandez-Gutierrez, B; Rodriguez-Rodriguez, L; de la Pena, PG; Vicente, E; Andreu, JL; de Castro, MF; Lopez-Longo, FJ; Martinez, L; Fonollosa, V; Guillen, A; Espinosa, G; Tolosa, C; Pros, A; Rodriguez-Carballeira, M; Narvaez, FJ; Rubio-Rivas, M; Ortiz-Santamaria, V; Madronero, AB; Gonzalez-Gay, MA; Diaz, B; Trapiella, L; Sousa, A; Egurbide, MV; Fanlo-Mateo, P; Saez-Comet, L; Diaz, F; Hernandez, V; Beltran, E; Roman-Ivorra, JA; Grau, E; Alegre-Sancho, JJ; Freire, M; Blanco-Garcia, FJ; Oreiro, N; Witte, T; Kreuter, A; Riemekasten, G; Airo, P; Magro, C; Voskuyl, AE; Vonk, MC; Hesselstrand, R; Proudman, S; Stevens, W; Nikpour, M; Zochling, J; Sahhar, J; Roddy, J; Nash, P; Tymms, K; Rischmueller, M; Lester, S; Vyse, T; Herrick, AL; Worthington, J; Denton, CP; Allanore, Y; Brown, MA; Radstake, TRDJ; Fonseca, C; Chang, HY; Mayes, MD; Martin, J

GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways

NATURE COMMUNICATIONS, 2019;

FI:11,878; D1

Mensa-Vilaro, A; Garcia-Morato, MB; de la Calle-Martin, O; Franco-Jarava, C; Martinez-Saavedra, MT; Gonzalez-Granado, LI; Gonzalez-Roca, E; Fuster, JL; Alsina, L; Mutchinick, OM; Balderrama-Rodriguez, A; Ramos, E; Modesto, C; Mesa-del-Castillo, P; Ortego-Centeno, N; Clemente, D; Souto, A; Palmou, N; Remesal, A; Leslie, KS; de la Fuente, EG; Gallego, LYB; Campistol, JM; Dhouib, NG; Bejaoui, M; Dutra, LA; Terreri, MT; Mosquera, C; Gonzalez, T; Canellas, J; de Morales, JMGR; Wouters, CH; Bosque, MT; Cham, WT; Jimenez-Trevino, S; de Inocencio, J; Bloomfield, M; de Diego, RP; Martinez-Pomar, N; Rodriguez-Pena, R; Gonzalez-Santesteban, C; Soler-Palacin, P; Casals, F; Yague, J; Allende, LM; Rodriguez-Gallego, JC; Colobran, R; Martinez-Martinez, L; Lopez-Granados, E; Arostegui, JI

Unexpected relevant role of gene mosaicism in patients with primary immunodeficiency diseases

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2019;

FI:14,11; D1

Marquez, A; Kerick, M; Zhernakova, A; Gutierrez-Achury, J; Chen, WM; Onengut-Gumuscu, S; Gonzalez-Alvaro, I; Rodriguez-Rodriguez, L; Rios-Fernandez, R; Gonzalez-Gay, MA; Mayes, MD; Raychaudhuri, S; Rich, SS; Wijmenga, C; Martin, J

Meta-analysis of Immunochip data of four autoimmune diseases reveals novel single-disease and cross-phenotype associations

GENOME MEDICINE, 2018;

FI:8,898; D1

Martorana, D; Marquez, A; Carmona, FD; Bonatti, F; Adorni, A; Urban, ML; Maritati, F; Buttini, EA; Marvisi, C; Palmisano, A; Rossi, GM; Trivioli, G; Fenaroli, P; Manenti, L; Nicastro, M; Incerti, M; Gianfreda, D; Bani, S; Ferretti, S; Corradi, D; Alberici, F; Emmi, G; Di Scala, G; Moroni, G; Percesepe, A; Scheel, PJ; Vermeer, E; van Bommel, EF; Martin, J; Vaglio, A

A large-scale genetic analysis reveals an autoimmune origin of idiopathic retroperitoneal fibrosis

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2018;

FI:13,258; D1

Martin-Varillas, JL; Calvo-Rio, V; Beltran, E; Sanchez-Burson, J; Mesquida, M; Adan, A; Hernandez, MV; Garfella, MH; Pascual, EV; Martinez-Costa, L; Sellas-Fernandez, A; Cordero-Coma, M; Diaz-Llopis, M; Gallego, R; Salom, D; Ortego, N; Garcia-Serrano, JL; Callejas-Rubio, JL; Herreras, JM; Garcia-Aparicio, A; Maiz, O; Blanco, A; Torre, I; Diaz-Valle, D; Pato, E; Aurrecoechea, E; Caracuel, MA; Gamero, F; Minguez, E; Carrasco-Cubero, C; Olive, A; Vazquez, J; Ruiz-Moreno, O; Manero, J; Munoz-Fernandez, S; Martinez, MG; Rubio-Romero, E; de Miera, FJTS; Longo, FJL; Nolla, JM; Revenga, M; Gonzalez-Vela, C; Loricera, J; Atienza-Mateo, B; Demetrio-Pablo, R; Hernandez, JL; Gonzalez-Gay, MA; Blanco, R

Successful Optimization of Adalimumab Therapy in Refractory Uveitis Due to Behcet’s Disease

OPHTHALMOLOGY, 2018;

FI:7,479; D1

Soriano-Maldonado, A; Morillas-de-Laguno, P; Sabio, JM; Gavilan-Carrera, B; Rosales-Castillo, A; Montalban-Mendez, C; Saez-Uran, LM; Callejas-Rubio, JL; Vargas-Hitos, JA

Effects of 12-week Aerobic Exercise on Arterial Stiffness, Inflammation, and Cardiorespiratory Fitness in Women with Systemic LUPUS Erythematosus: Non-Randomized Controlled Trial

JOURNAL OF CLINICAL MEDICINE, 2018;

FI:5,583; D1

Gonzalez-Serna, D; Carmona, EG; Ortego-Centeno, N; Simeon, CP; Solans, R; Hernandez-Rodriguez, J; Tolosa, C; Castaneda, S; Narvaez, J; Martinez-Valle, F; Witte, T; Neumann, T; Holle, J; Beretta, L; Boiardi, L; Emmi, G; Cimmino, MA; Vaglio, A; Herrick, AL; Denton, CP; Salvarani, C; Cid, MC; Morgan, AW; Fonseca, C; Gonzalez-Gay, MA; Martin, J; Marquez, A

A TNFSF13B functional variant is not involved in systemic sclerosis and giant cell arteritis susceptibility

PLOS ONE, 2018;

FI:2,766; Q1

Trapiella-Martinez, L; Diaz-Lopez, JB; Caminal-Montero, L; Tolosa-Vilella, C; Castillo, AGD; Colunga-Arguelles, D; Rubio-Rivas, M; Iniesta-Arandia, N; Castillo-Palma, MJ; Saez-Comet, L; Egurbide-Arberas, MV; Ortego-Centeno, N; Freire, M; Vargas-Hitos, JA; Rios-Blanco, JJ; Todoli-Parra, JA; Rodriguez-Carballeira, M; Marin-Ballve, A; Chamorro-Fernandez, AJ; Pla-Salas, X; Madronero-Vuelta, AB; Ruiz-Munoz, M; Fonollosa-Pla, V; Simeon-Aznar, CP

Very early and early systemic sclerosis in the Spanish scleroderma Registry (RESCLE) cohort

AUTOIMMUNITY REVIEWS, 2017;

FI:8,961; D1

Bartoloni, E; Gonzalez-Gay, MA; Scire, C; Castaneda, S; Gerli, R; Lopez-Longo, FJ; Martinez-Barrio, J; Govoni, M; Furini, F; Pina, T; Iannone, F; Giannini, M; Nuno, L; Quartuccio, L; Ortego-Centeno, N; Alunno, A; Specker, C; Montecucco, C; Triantafyllias, K; Balduzzi, S; Sifuentes-Giraldo, WA; Paolazzi, G; Bravi, E; Schwarting, A; Pellerito, R; Russo, A; Selmi, C; Saketkoo, LA; Fusaro, E; Parisi, S; Pipitone, N; Franceschini, F; Cavazzana, I; Neri, R; Barsotti, S; Codullo, V; Cavagna, L

Clinical follow-up predictors of disease pattern change in anti-Jo1 positive anti-synthetase syndrome: Results from a multicenter, international and retrospective study

AUTOIMMUNITY REVIEWS, 2017;

FI:8,961; D1

Langefeld, CD; Ainsworth, HC; Graham, DSC; Kelly, JA; Comeau, ME; Marion, MC; Howard, TD; Ramos, PS; Croker, JA; Morris, DL; Sandling, JK; Almlof, JC; Acevedo-Vasquez, EM; Alarcon, GS; Babini, AM; Baca, V; Bengtsson, AA; Berbotto, GA; Bijl, M; Brown, EE; Brunner, HI; Cardiel, MH; Catoggio, L; Cervera, R; Cucho-Venegas, JM; Dahlqvist, SR; D'Alfonso, S; Silva, BM; Figueroa, ID; Doria, A; Edberg, JC; Endreffy, E; Esquivel-Valerio, JA; Fortin, PR; Freedman, BI; Frostegard, J; Garcia, MA; de la Torre, IG; Gilkeson, GS; Gladman, DD; Gunnarsson, I; Guthridge, JM; Huggins, JL; James, JA; Kallenberg, CGM; Kamen, DL; Karp, DR; Kaufman, KM; Kottyan, LC; Kovacs, L; Laustrup, H; Lauwerys, BR; Li, QZ; Maradiaga-Cecena, MA; Martin, J; McCune, JM; McWilliams, DR; Merrill, JT; Miranda, P; Moctezuma, JF; Nath, SK; Niewold, TB; Orozco, L; Ortego-Centeno, N; Petri, M; Pineau, CA; Pons-Estel, BA; Pope, J; Raj, P; Ramsey-Goldman, R; Reveille, JD; Russell, LP; Sabio, JM; Aguilar-Salinas, CA; Scherbarth, HR; Scorza, R; Seldin, MF; Sjowall, C; Svenungsson, E; Thompson, SD; Toloza, SMA; Truedsson, L; Tusie-Luna, T; Vasconcelos, C; Vila, LM; Wallace, DJ; Weisman, MH; Wither, JE; Bhangale, T; Oksenberg, JR; Rioux, JD; Gregersen, PK; Syvanen, AC; Ronnblom, L; Criswell, LA; Jacob, CO; Sivils, KL; Tsao, BP; Schanberg, LE; Behrens, TW; Silverman, ED; Alarcon-Riquelme, ME; Kimberly, RP; Harley, JB; Wakeland, EK; Graham, RR; Gaffney, PM; Vyse, TJ

Transancestral mapping and genetic load in systemic lupus erythematosus

NATURE COMMUNICATIONS, 2017;

FI:12,124; D1

Lopez-Isac, E; Bossini-Castillo, L; Palma, AB; Assassi, S; Mayes, MD; Simeon, CP; Ortego-Centeno, N; Vicente, E; Tolosa, C; Rubio-Rivas, M; Roman-Ivorra, JA; Beretta, L; Moroncini, G; Hunzelmann, N; Distler, JHW; Riemekasten, G; de Vries-Bouwstra, J; Voskuyl, AE; Radstake, TRDJ; Herrick, A; Denton, CP; Fonseca, C; Martin, J

Analysis of ATP8B4 F436L Missense Variant in a Large Systemic Sclerosis Cohort

ARTHRITIS & RHEUMATOLOGY, 2017;

FI:6,918; D1

Marquez, A; Vidal-Bralo, L; Rodriguez-Rodriguez, L; Gonzalez-Gay, MA; Balsa, A; Gonzalez-Alvaro, I; Carreira, P; Ortego-Centeno, N; Ayala-Gutierrez, MM; Garcia-Hernandez, FJ; Gonzalez-Escribano, MF; Sabio, JM; Tolosa, C; Suarez, A; Gonzalez, A; Padyukov, L; Worthington, J; Vyse, T; Alarcon-Riquelme, ME; Martin, J

A combined large-scale meta-analysis identifies COG6 as a novel shared risk locus for rheumatoid arthritis and systemic lupus erythernatosus

ANNALS OF THE RHEUMATIC DISEASES, 2017;

FI:12,811; D1

Lopez-Isac, E; Campillo-Davo, D; Bossini-Castillo, L; Guerra, SG; Assassi, S; Simeon, CP; Carreira, P; Ortego-Centeno, N; de la Pena, PG; Beretta, L; Santaniello, A; Bellocchi, C; Lunardi, C; Moroncini, G; Gabrielli, A; Riemekasten, G; Witte, T; Hunzelmann, N; Kreuter, A; Distler, JHW; Voskuyl, AE; de Vries-Bouwstra, J; Herrick, A; Worthington, J; Denton, CP; Fonseca, C; Radstake, TRDJ; Mayes, MD; Martin, J

Influence of TYK2 in systemic sclerosis susceptibility: a new locus in the IL-12 pathway

ANNALS OF THE RHEUMATIC DISEASES, 2016;

FI:12,384; D1

Demelo-Rodriguez, P; Ortego-Centeno, N; Callejas-Rubio, JL

Groove sign

EUROPEAN JOURNAL OF INTERNAL MEDICINE, 2016;

FI:2,591; Q1

Marquez, A; Martin, J; Carmona, FD

Emerging aspects of molecular biomarkers for diagnosis, prognosis and treatment response in rheumatoid arthritis

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2016;

FI:3,333; Q1

Lopez-Isac, E; Martin, JE; Assassi, S; Simeon, CP; Carreira, P; Ortego-Centeno, N; Freire, M; Beltran, E; Narvaez, J; Alegre-Sancho, JJ; Fernandez-Gutierrez, B; Balsa, A; Ortiz, AM; Gonzalez-Gay, MA; Beretta, L; Santaniello, A; Bellocchi, C; Lunardi, C; Moroncini, G; Gabrielli, A; Witte, T; Hunzelmann, N; Distler, JHW; Riekemasten, G; van der Helm-Van Mil, AH; de Vries-Bouwstra, J; Magro-Checa, C; Voskuyl, AE; Vonk, MC; Molberg, O; Merriman, T; Hesselstrand, R; Nordin, A; Padyukov, L; Herrick, A; Eyre, S; Koeleman, BPC; Denton, CP; Fonseca, C; Radstake, TRDJ; Worthington, J; Mayes, MD; Martin, J

IRF4 Newly Identified as a Common Susceptibility Locus for Systemic Sclerosis and Rheumatoid Arthritis in a Cross-Disease Meta-Analysis of Genome-Wide Association Studies

ARTHRITIS & RHEUMATOLOGY, 2016;

FI:6,009; Q1

Ortiz-Fernandez, L; Carmona, FD; Montes-Cano, MA; Garcia-Lozano, JR; Conde-Jaldon, M; Ortego-Centeno, N; Castillo, MJ; Espinosa, G; Grana-Gil, G; Sanchez-Burson, J; Julia, MR; Solans, R; Blanco, R; Barnosi-Marin, AC; de la Torre, RG; Fanlo, P; Rodriguez-Carballeira, M; Rodriguez-Rodriguez, L; Camps, T; Castaneda, S; Alegre-Sancho, JJ; Martin, J; Gonzalez-Escribano, MF

Genetic Analysis with the Immunochip Platform in Behcet Disease. Identification of Residues Associated in the HLA Class I Region and New Susceptibility Loci

PLOS ONE, 2016;

FI:3,057; Q1

Cavagna, L; Nuno, L; Scire, CA; Govoni, M; Longo, FJL; Franceschini, F; Neri, R; Castaneda, S; Giraldo, WAS; Caporali, R; Iannone, F; Fusaro, E; Paolazzi, G; Pellerito, R; Schwarting, A; Saketkoo, LA; Ortego-Centeno, N; Quartuccio, L; Bartoloni, E; Specker, C; Murcia, TP; La Corte, R; Furini, F; Foschi, V; Corral, JB; Airo, P; Cavazzana, I; Martinez-Barrio, J; Hinojosa, M; Giannini, M; Barsotti, S; Menke, J; Triantafyllias, K; Vitetta, R; Russo, A; Bajocchi, G; Bravi, E; Barausse, G; Bortolotti, R; Selmi, C; Parisi, S; Montecucco, C; Gonzalez-Gay, MA

Clinical Spectrum Time Course in Anti Jo-1 Positive Antisynthetase Syndrome Results From an International Retrospective Multicenter Study

MEDICINE, 2015;

FI:5,723; D1

Oparina, NY; Delgado-Vega, AM; Martinez-Bueno, M; Magro-Checa, C; Fernandez, C; Castro, RO; Pons-Estel, BA; D'Alfonso, S; Sebastiani, GD; Witte, T; Lauwerys, BR; Endreffy, E; Kovacs, L; Escudero, A; Lopez-Pedrera, C; Vasconcelos, C; da Silva, BM; Frostegard, J; Truedsson, L; Martin, J; Raya, E; Ortego-Centeno, N; Aguirre, MD; Garrido, ED; Palma, MJC; Alarcon-Riquelme, ME; Kozyrev, SV

PXK locus in systemic lupus erythematosus: fine mapping and functional analysis reveals novel susceptibility gene ABHD6

ANNALS OF THE RHEUMATIC DISEASES, 2015;

FI:10,377; D1

Simeon-Aznar, CP; Fonollosa-Pla, V; Tolosa-Vilella, C; Espinosa-Garriga, G; Campillo-Grau, M; Ramos-Casals, M; Garcia-Hernandez, FJ; Castillo-Palma, MJ; Sanchez-Roman, J; Callejas-Rubio, JL; Ortego-Centeno, N; Egurbide-Arberas, MV; Trapiellla-Martinez, L; Caminal-Montero, L; Saez-Comet, L; Velilla-Marco, J; Camps-Garcia, MT; de Ramon-Garrido, E; Esteban-Marcos, EM; Pallares-Ferreres, L; Navarrete-Navarrete, N; Vargas-Hitos, JA; de la Torre, RG; Salvador-Cervello, G; Rios-Blanco, JJ; Vilardell-Tarres, M

Registry of the Spanish Network for Systemic Sclerosis Survival, Prognostic Factors, and Causes of Death

MEDICINE, 2015;

FI:5,723; D1

Nakagawa, K; Gonzalez-Roca, E; Souto, A; Kawai, T; Umebayashi, H; Campistol, JM; Canellas, J; Takei, S; Kobayashi, N; Callejas-Rubio, JL; Ortego-Centeno, N; Ruiz-Ortiz, E; Rius, F; Anton, J; Iglesias, E; Jimenez-Trevino, S; Vargas, C; Fernandez-Martin, J; Calvo, I; Hernandez-Rodriguez, J; Mendez, M; Dordal, MT; Basagana, M; Bujan, S; Yashiro, M; Kubota, T; Koike, R; Akuta, N; Shimoyama, K; Iwata, N; Saito, MK; Ohara, O; Kambe, N; Yasumi, T; Izawa, K; Kawai, T; Heike, T; Yague, J; Nishikomori, R; Arostegui, JI

Somatic NLRP3 mosaicism in Muckle-Wells syndrome. A genetic mechanism shared by different phenotypes of cryopyrin-associated periodic syndromes

ANNALS OF THE RHEUMATIC DISEASES, 2015;

FI:10,377; D1

Riancho-Zarrabeitia, L; Calvo-Rio, V; Blanco, R; Mesquida, M; Adan, AM; Herreras, JM; Aparicio, A; Peiteado-Lopez, D; Cordero-Coma, M; Serrano, JLG; Ortego-Centeno, N; Maiz, O; Blanco, A; Sanchez-Burson, J; Gonzalez-Suarez, S; Fonollosa, A; Santos-Gomez, M; Gonzalez-Vela, C; Loricera, J; Pina, T; Gonzalez-Gay, MA

Anti-TNF-alpha therapy in refractory uveitis associated with sarcoidosis: Multicenter study of 17 patients

SEMINARS IN ARTHRITIS AND RHEUMATISM, 2015;

FI:3,925; Q1

Elaboración de un atlas celular diferenciado por sexo de tejido cutáneo en pacientes con esclerosis sistémica mediante secuenciación del transcriptoma de célula única

Financiador: INSTITUTO DE SALUD CARLOS III - FEDER

Número de expediente: PI22/00092

Tiempo de ejecución: 01/01/2023 - 31/12/2025

IP: MARIALBERT ACOSTA HERRERA

AOVELES_Efecto del Aceite de Oliva Virgen extra en el Lupus Eritematoso Sistémico

Financiador: UNIVERSIDAD DE GRANADA

Número de expediente: B-CTS-100-UGR20

Tiempo de ejecución: 01/07/2021 - 30/06/2023

IP: BLANCA MARIA RUEDA MEDINA

Detección Precoz de Osteoporosis: Identificación de Factores Genéticos Implicados en la Mineralización Ósea en Adultos Jóvenes

Financiador: FUNDACION PUBLICA ANDALUZA PROGRESO Y SALUD

Número de expediente: PI-0414-2014

Tiempo de ejecución: 31/07/2015 - 01/08/2017

IP: BLANCA MARIA RUEDA MEDINA

Identificación de Factores Genéticos Implicados en el Desarrollo de Úlceras Digitales en Pacientes de Esclerodermia Mediante Un Estudio de Asociación del Genoma Completo (Gwas)

Financiador: FUNDACION PUBLICA ANDALUZA PROGRESO Y SALUD

Número de expediente: PI-0390-2014

Tiempo de ejecución: 31/07/2015 - 01/08/2017

Lydimed: Lupus y Dieta Mediterránea

Financiador: CONSEJERÍA DE SALUD

Número de expediente: PI-0523-2016

Tiempo de ejecución: 01/01/2017 - 31/12/2019

Identificación de Factores Genéticos de Riesgo Compartidos Entre Enfermedades Reumáticas Mediante Una Estrategia Meta-Immunochip

Financiador: CONSEJERÍA DE SALUD

Número de expediente: PI-0493-2016

Tiempo de ejecución: 01/01/2017 - 31/12/2019

IP: RAQUEL RIOS FERNANDEZ

Study of the molecular basis of giant cell arteritis by integrating genomic, transcriptomic and methylation data.

Financiador: INSTITUTO DE SALUD CARLOS III - FEDER

Número de expediente: CP17/00008-P

Tiempo de ejecución: 01/01/2018 - 31/12/2020

Identificación de los mecanismos patogénicos implicados en el desarrollo de la arteritis de células gigantes mediante secuenciación del transcriptoma de células T individuales

Financiador: INSTITUTO DE SALUD CARLOS III - FEDER

Número de expediente: PI18/00040

Tiempo de ejecución: 01/01/2019 - 31/12/2021

Estudio fase 2/3, aleatorizado, doble ciego, controlado con placebo, de grupos paralelos para evaluar la eficacia y la seguridad de belimumab administrado por vía subcutánea en adultos con enfermedad pulmonar intersticial asociada a esclerosis sistémica (

Financiador: GLAXOSMITHKLINE, S.A.

Tipo de prueba: ENSAYO CLÍNICO CON MEDICAMENTOS

Tiempo de ejecución: 17/07/2023 - 30/05/2027

IP: JOSE LUIS CALLEJAS RUBIO

Ensayo abierto multicéntrico aleatorizado y pragmático de fase III para Evaluar la eficacia y seguridad de diferentes duraciones de tratamiento Antimicrobiano de infecciones asociadas al material de osteosíntesis tras Fractura de hueso largo (DURATIOM)

Financiador: FUNDACION PARA LA GESTION DE LA INVESTIGACIÓN EN SALUD DE SEVILLA

Tipo de prueba: ENSAYO CLÍNICO CON MEDICAMENTOS

Tiempo de ejecución: 20/06/2023 - 30/10/2024

IP: MARIA CONCEPCION FERNANDEZ ROLDAN

Ensayo en 2 etapas multicéntrico, aleatorizado, doble ciego y comparativo con placebo para evaluar la eficacia y la seguridad de Telitacicept controlado con placebo en pacientes con lupus eritematoso sistémico activo moderado o grave.

Financiador: REMEGEN CO. LTD

Tipo de prueba: ENSAYO CLÍNICO CON MEDICAMENTOS

Tiempo de ejecución: 17/02/2023 - 30/01/2024

IP: JOSE LUIS CALLEJAS RUBIO

Estudio de fase II, aleatorizado, doble ciego, controlado con placebo, de grupos paralelos, de eficacia y seguridad de por lo menos 48 semanas de tratamiento con BI 685509 por vía oral en adultos con esclerosis sistémica progresiva.

Financiador: BOEHRINGER INGELHEIM ESPAÑA, S.A.

Tipo de prueba: ENSAYO CLÍNICO CON MEDICAMENTOS

Tiempo de ejecución: 20/12/2022 - 30/01/2026

IP: JOSE LUIS CALLEJAS RUBIO

Estudio de fase III, multicéntrico, aleatorizado, doble ciego y controlado con placebo para evaluar la eficacia y la seguridad de BIIB059 en participantes adultos con lupus eritematoso sistémico activo que reciben de base tratamiento estándar no biológico para el lupus.(TOPAZ-1)

Financiador: BIOGEN IDEC RESEARCH LIMITED

Tipo de prueba: ENSAYO CLINICO COMERCIAL

Tiempo de ejecución: 03/01/2022 - 30/09/2026

IP: JOSE LUIS CALLEJAS RUBIO

Un estudio de 52 semanas, aleatorizado, doble ciego, con doble simulación, de grupos paralelos, multicéntrico, de no inferioridad para investigar la eficacia y seguridad de depemokimab en comparación con mepolizumab en adultos con granulomatosis eosinofílica con poliangeítis (EGPA, por sus siglas en inglés) recidivante o refractaria que reciben el tratamiento habitual

Financiador: GLAXOSMITHKLINE RESEARCH DEVELOPMENT LTD

Tipo de prueba: ENSAYO CLINICO COMERCIAL

Tiempo de ejecución: 03/08/2022 - 08/10/2025

IP: JOSE LUIS CALLEJAS RUBIO

Ensayo clínico de Sarilumab en adultos hospitalizados con COVID-19 que presentan síndrome de liberación de citoquinas (SARICOR)

Financiador: FUNDACION UNIVERSITARIA PARA EL DESARROLLO DE LA PROVINCIA DE CORDOBA

Tipo de prueba: ENSAYO CLINICO INDEPENDIENTE

Tiempo de ejecución: 07/05/2020 -

IP: MARIA CONCEPCION FERNANDEZ ROLDAN

CDC Ensayo clínico abierto y multicéntrico para evaluar la efectividad y seguridad de tocilizumab intravenoso en el tratamiento de pacientes con neumonía por COVID-19. Estudio BREATH-19

Financiador: FUNDACION SEIMC-GESIDA

Tipo de prueba: ENSAYO CLINICO INDEPENDIENTE

Tiempo de ejecución: 22/05/2020 - 20/11/2020

IP: JOSE LUIS CALLEJAS RUBIO

MP07-Bases Fisiopatología y Terapéutica Médica

Líneas de investigación

Palabras clave

SARA DEL OLMO ROMERO

MARIA DEL ROCIO GIL GUTIERREZ

MARTA GARCIA MORALES

JAVIER DE LA HERA FERNANDEZ

MARIALBERT ACOSTA HERRERA

ELIO GABRIEL CARMONA RUBIO

JOSE LUIS CALLEJAS RUBIO

MARIA CORREA RODRIGUEZ

MARIA CONCEPCION FERNANDEZ ROLDAN

RAQUEL RIOS FERNANDEZ

BLANCA MARIA RUEDA MEDINA

Investigación