A04-Patología Digital y Computacional, Inmunopatología y Cáncer

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Grupo de investigación aplicada traslacional en cáncer, ginecopatología e inmunopatología. Su línea principal de investigación se centra en la identificación de nuevos marcadores de interés pronóstico y diagnóstico en el cáncer. También se realiza investigación sobre la biopatología del carcinoma oral de células escamosas, encaminada esencialmente el análisis de marcadores de proliferación celular en epitelios premalignos y en tejido tumoral, así como el estudio de proteínas estimuladas de la proliferación. En los últimos años la línea principal del grupo se ha dirigido al campo de expresión de marcadores de células madre cancerosas en epitelio premaligno y cáncer oral. En la actualidad por medio de herramientas de patología digital y patología computacional nuestro grupo de investigación está desarrollando modelos de aprendizaje por Deep-learning como nueva línea en investigación del cáncer.

Líneas de investigación

Identificación de nuevos marcadores de interés pronóstico y diagnóstico en el cáncer
Marcadores de células madre cancerosas en epitelio premaligno y cáncer oral
Desarrollo de modelos de aprendizaje profundo (Deep-learning) para identificación de nuevos patrones en cáncer
Detección de marcadores genéticos implicados en la resistencia al tratamiento con trastuzumab en pacientes con cáncer de mama
Farmacogenética del cáncer de colon metastásico en pacientes tratados con esquemas de 5FU y anticuerpos monoclonales
Nefropatología, trasplante renal y uropatología. Modelos clínico patológicos, experimentales y patología del donante
Neuropatología tumoral
Patología de la cavidad oral
Patología de la piel y tejidos blandos. Marcadores inmunohistoquímicos en neoplasias
Patología digital y computacional
Patología ginecológica
Patología oral y de la cabeza y cuello
Patología viral: HPV y su relación con la carcinogénesis en tumores del tracto genital y otras localizaciones

Palabras clave

Cáncer, diagnóstico, pronóstico, genética, molecular

BEATRIZ RUEDA VILLAFRANCA

JULIO MERINO MONTES

ORCID

ALBERTO JOSE GREGORIO ALVAREZ LUCENA

OVIDIU PREDA

CESAR RAMIREZ TORTOSA

ORCID

FRANCISCO MANUEL RAMOS PLEGUEZUELOS

ROSA RIOS PELEGRINA

ORCID

ANA ISABEL ROMERO ORTIZ

JOSEFA RUBI URIA

ISABEL RUIZ AVILA

ANA MARIA SEGURA PEREZ

ORCID

MARIA ESTHER VERGARA ALCAIDE

CESAR GARCIA LOPEZ

RAIMUNDO GARCIA DEL MORAL GARRIDO

JOSE ANTONIO GIL MONTOYA

ORCID

MIGUEL ANGEL GONZALEZ MOLES

ORCID

RODRIGO LOPEZ CASTRO

JAVIER LUIS LOPEZ HIDALGO

ORCID

AURELIO MARTIN CASTRO

Mª TERESA MEDINA CANO

MARGARITA MERINO ALVAREZ

IGNACIO J MOLINA PINEDA DE LAS INFANTAS

FRANCISCO JAVIER O’VALLE RAVASSA

DAVID AGUILAR PEÑA

ORCID

JOSE ANEIROS FERNANDEZ

PATRICIA BECERRA MASSARE

MERCEDES CABA MOLINA

ORCID

CLARA EUGENIA CHAMORRO SANTOS

INMACULADA GARCIA PEREZ

del Amor, R; Pérez-Cano, J; López-Pérez, M; Terradez, L; Aneiros-Fernandez, J; Morales, S; Mateos, J; Molina, R; Naranjo, V

Annotation protocol and crowdsourcing multiple instance learning classification of skin histological images: The CR-AI4SkIN dataset

ARTIFICIAL INTELLIGENCE IN MEDICINE, 2023;

FI:7,5; Q1

Diaz-Ruano, AB; Martinez-Alarcon, N; Perán, M; Benabdellah, K; Garcia-Martinez, MD; Preda, O; Ramirez-Tortosa, C; Gonzalez-Hernandez, A; Marchal, JA; Picon-Ruiz, M

Estradiol and Estrone Have Different Biological Functions to Induce NF-κB-Driven Inflammation, EMT and Stemness in ER plus Cancer Cells

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023;

FI:6,208; Q1

Galindo-Moreno, P; Martín-Morales, N; Olaechea, A; Hernández-Cortes, P; Verdugo-Escamilla, C; Martinez-Ruiz, F; Carrillo-Galvez, AB; O'Valle, F; Padial-Molina, M

Physico-chemical and biological characterization of a new bovine bone mineral matrix available for human usage

CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH, 2023;

FI:3,6; Q1

González-Correa, C; Moleón, J; Miñano, S; Robles-Vera, I; Toral, M; Martín-Morales, N; O'Valle, F; Sánchez, M; Gómez-Guzmán, M; Jiménez, R; Romero, M; Duarte, J

Mineralocorticoid receptor blockade improved gut microbiota dysbiosis by reducing gut sympathetic tone in spontaneously hypertensive rats

BIOMEDICINE & PHARMACOTHERAPY, 2023;

FI:7,5; Q1

Gil-Montoya, JA; Rivero-Blanco, T; Leon-Rios, X; Exposito-Ruiz, M; Pérez-Castillo, ; Aguilar-Cordero, MJ

Oral and general health conditions involved in periodontal status during pregnancy: a prospective cohort study

ARCHIVES OF GYNECOLOGY AND OBSTETRICS, 2023;

FI:2,6; Q3

Benitez, R; Caro, M; Andres-Leon, E; O'Valle, F; Delgado, M

Cortistatin regulates fibrosis and myofibroblast activation in experimental hepatotoxic- and cholestatic-induced liver injury

BRITISH JOURNAL OF PHARMACOLOGY, 2022;

FI:9,473; D1

Gonzalez-Moles, MA; Aguilar-Ruiz, M; Ramos-Garcia, P

Challenges in the Early Diagnosis of Oral Cancer, Evidence Gaps and Strategies for Improvement: A Scoping Review of Systematic Reviews

CANCERS, 2022;

FI:6,575; Q1

Varela-Lopez, A; Ramirez-Tortosa, CL; Ramos-Pleguezuelos, FM; Marquez-Lobo, B; Battino, M; Quiles, JL

Differences reported in the lifespan and aging of male Wistar rats maintained on diets containing fat with different fatty acid profiles (virgin olive, sunflower or fish oils) are not reflected by histopathological lesions found at death in central nervous and endocrine systems

FOOD AND CHEMICAL TOXICOLOGY, 2022;

FI:5,572; Q1

Galindo-Moreno, P; Catena, A; Perez-Sayans, M; Fernandez-Barbero, JE; O'Valle, F; Padial-Molina, M

Early marginal bone loss around dental implants to define success in implant dentistry: A retrospective study

CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH, 2022;

FI:4,259; Q1

Domingo-Reines, J; Martinez-Navajas, G; Montes, R; Lamolda, M; Simon, I; Castano, J; Rios-Pelegrina, R; Lopez-Hidalgo, JL; del Moral, RG; Marchal, JA; Real, PJ; Ramos-Mejia, V

Generation of a H9 Clonal Cell Line With Inducible Expression of NUP98-KDM5A Fusion Gene in the AAVS1 Safe Harbor Locus.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022;

FI:6,081; Q1

Diaz-Alcazar, MM; Lopez-Hidalgo, JL; Aneiros-Fernandez, J

Acute pancreatitis manifesting in the skin: Pancreatic panniculitis.

REVISTA DE GASTROENTEROLOGIA DE MEXICO, 2021;

Gonzalez-Moles, MA; Ramos-Garcia, P; Warnakulasuriya, S

A Scoping Review on Gaps in the Diagnostic Criteria for Proliferative Verrucous Leukoplakia: A Conceptual Proposal and Diagnostic Evidence-Based Criteria

CANCERS, 2021;

FI:6,639; Q1

Gonzalez-Moles, MA; Ramos-Garcia, P; Warnakulasuriya, S

An appraisal of highest quality studies reporting malignant transformation of oral lichen planus based on a systematic review

ORAL DISEASES, 2021;

FI:3,511; Q1

Seoane, J; Warnakulasuriya, S; Bagan, JV; Aguirre-Urizar, JM; Lopez-Jornet, P; Hernandez-Vallejo, G; Gonzalez-Moles, MA; Pereiro-Ferreiros, M; Seoane-Romero, J; Varela-Centelles, P

Assembling a consensus on actinic cheilitis: A Delphi study

JOURNAL OF ORAL PATHOLOGY & MEDICINE, 2021;

FI:4,253; Q1

Perez-Bueno, F; Vega, M; Sales, MA; Aneiros-Fernandez, J; Naranjo, V; Molina, R; Katsaggelos, AK

Blind color deconvolution, normalization, and classification of histological images using general super Gaussian priors and Bayesian inference

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE, 2021;

FI:5,428; Q1

Galindo-Moreno, P; Padial-Molina, M; Lopez-Chaichio, L; Gutierrez-Garrido, L; Martin-Morales, N; O'Valle, F

Algae-derived hydroxyapatite behavior as bone biomaterial in comparison with anorganic bovine bone: A split-mouth clinical, radiological, and histologic randomized study in humans

CLINICAL ORAL IMPLANTS RESEARCH, 2020;

FI:3,723; D1

Varela-Lopez, A; Bullon, P; Ramirez-Tortosa, CL; Navarro-Hortal, MD; Robles-Almazan, M; Bullon, B; Cordero, MD; Battino, M; Quiles, JL

A Diet Rich in Saturated Fat and Cholesterol Aggravates the Effect of Bacterial Lipopolysaccharide on Alveolar Bone Loss in a Rabbit Model of Periodontal Disease

NUTRIENTS, 2020;

FI:4,546; Q1

Chamoun, B; Caraben, A; Torres, IB; Sellares, J; Jimenez, R; Toapanta, N; Cidraque, I; Gabaldon, A; Perello, M; Gonzalo, R; O'Valle, F; Moreso, F; Seron, D

A Rejection Gene Expression Score in Indication and Surveillance Biopsies Is Associated with Graft Outcome

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020;

FI:4,556; Q1

Lenouvel, D; Gonzalez-Moles, MA; Talbaoui, A; Ramos-Garcia, P; Gonzalez-Ruiz, L; Ruiz-Avila, I; Gil-Montoya, JA

An update of knowledge on PD-L1 in head and neck cancers: Physiologic, prognostic and therapeutic perspectives

ORAL DISEASES, 2020;

FI:2,613; Q1

Rosales-Castillo, A; Hidalgo, JL; Tenorio, CH

A rare cause of chronic diarrhea

ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA, 2020;

FI:1,654; Q4

Gonzalez-Moles, MA; Ruiz-Avila, I; Gonzalez-Ruiz, L; Ayen, A; Gil-Montoya, JA; Ramos-Garcia, P

Malignant transformation risk of oral lichen planus: A systematic review and comprehensive meta-analysis

ORAL ONCOLOGY, 2019;

FI:3,73; D1

del Castillo-Santaella, T; Ortega-Oller, I; Padial-Molina, M; O'Valle, F; Galindo-Moreno, P; Jodar-Reyes, AB; Peula-Garcia, JM

Formulation, Colloidal Characterization, and In Vitro Biological Effect of BMP-2 Loaded PLGA Nanoparticles for Bone Regeneration

PHARMACEUTICS, 2019;

FI:4,773; D1

Mendoza-Azpur, G; Olaechea, A; Padial-Molina, M; Gutierrez-Garrido, L; O'Valle, F; Mesa, F; Galindo-Moreno, P

Composite Alloplastic Biomaterial vs. Autologous Platelet-Rich Fibrin in Ridge Preservation

JOURNAL OF CLINICAL MEDICINE, 2019;

FI:5,688; D1

Olaechea, A; Mendoza-Azpur, G; O'Valle, F; Padial-Molina, M; Martin-Morales, N; Galindo-Moreno, P

Biphasic hydroxyapatite and ss-tricalcium phosphate biomaterial behavior in a case series of maxillary sinus augmentation in humans

CLINICAL ORAL IMPLANTS RESEARCH, 2019;

FI:3,825; D1

Toral, M; Robles-Vera, I; Romero, M; de la Visitacion, N; Sanchez, M; O'Valle, F; Rodriguez-Nogales, A; Galvez, J; Duarte, J; Jimenez, R

Lactobacillus fermentum CECT5716: a novel alternative for the prevention of vascular disorders in a mouse model of systemic lupus erythematosus

FASEB JOURNAL, 2019;

FI:5,391; D1

Ramos-Garcia, P; Gonzalez-Moles, MA; Gonzalez-Ruiz, L; Ruiz-Avila, I; Ayen, A; Gil-Montoya, JA

Prognostic and clinicopathological significance of cyclin D1 expression in oral squamous cell carcinoma: A systematic review and meta-analysis

ORAL ONCOLOGY, 2018;

FI:4,636; D1

Galindo-Moreno, P; de Buitrago, JG; Padial-Molina, M; Fernandez-Barbero, JE; Ata-Ali, J; O'Valle, F

Histopathological comparison of healing after maxillary sinus augmentation using xenograft mixed with autogenous bone versus allograft mixed with autogenous bone

CLINICAL ORAL IMPLANTS RESEARCH, 2018;

FI:4,305; D1

Sanchez-Munoz, A; Vicioso, L; Santonja, A; Alvarez, M; Plata-Fernandez, Y; Miramon, J; Zarcos, I; Ramirez-Tortosa, CL; Montes-Torres, J; Jerez, JM; de Luque, V; Llacer, C; Fernandez-De Sousa, CE; Perez-Villa, L; Alba, E

Male breast cancer: correlation between immunohistochemical subtyping and PAM50 intrinsic subtypes, and the subsequent clinical outcomes

MODERN PATHOLOGY, 2018;

FI:6,655; D1

Gonzalez-Gonzalez, A; Munoz-Muela, E; Marchal, JA; Cara, FE; Molina, MP; Cruz-Lozano, M; Jimenez, G; Verma, A; Ramirez, A; Qian, W; Chen, W; Kozielski, AJ; Elemento, O; Martin-Salvago, MD; Luque, RJ; Rosa-Garrido, C; Landeira, D; Quintana-Romero, M; Rosato, RR; Garcia, MA; Ramirez-Tortosa, CL; Kim, H; Rodriguez-Aguayo, C; Lopez-Berestein, G; Sood, AK; Lorente, JA; Sanchez-Rovira, P; Chang, JC; Granados-Principal, S

Activating Transcription Factor 4 Modulates TGF beta-Induced Aggressiveness in Triple-Negative Breast Cancer via SMAD2/3/4 and mTORC2 Signaling

CLINICAL CANCER RESEARCH, 2018;

FI:10,199; D1

Activating Transcription Factor 4 Modulates TGF beta-Induced Aggressiveness in Triple-Negative Breast Cancer via SMAD2/3/4 and mTORC2 Signaling

CLINICAL CANCER RESEARCH, 2018;

FI:10,199; D1

Ramos-Garcia, P; Ruiz-Avila, I; Gil-Montoya, JA; Ayen, A; Gonzalez-Ruiz, L; Navarro-Trivino, FJ; Gonzalez-Moles, MA

Relevance of chromosomal band 11q13 in oral carcinogenesis: An update of current knowledge

ORAL ONCOLOGY, 2017;

FI:4,794; D1

Ruiz-Villaverde, R; Garrido-Colmenero, C; Diaz-Martinez, MA; Aneiros-Fernandez, J

History, clinical findings, and histopathology Vulvar steatocystoma multiplex

JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, 2017;

FI:2,865; Q1

Perea, F; Bernal, M; Sanchez-Palencia, A; Carretero, J; Torres, C; Bayarri, C; Gomez-Morales, M; Garrido, F; Ruiz-Cabello, F

The absence of HLA class I expression in non-small cell lung cancer correlates with the tumor tissue structure and the pattern of T cell infiltration

INTERNATIONAL JOURNAL OF CANCER, 2017;

FI:6,513; Q1

Tejera-Vaquerizo, A; Perez-Cabello, G; Marinez-Leborans, L; Gallego, E; Oliver-Martinez, V; Martin-Cuevas, P; Arias-Santiago, S; Aneiros-Fernandez, J; Herrera-Acosta, E; Traves, V; Herrera-Ceballos, E; Nagore, E

Is mitotic rate still useful in the management of patients with thin melanoma?

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2017;

FI:3,528; Q1

Ramirez-Exposito, MJ; Urbano-Polo, N; Duenas, B; Navarro-Cecilia, J; Ramirez-Tortosa, C; Martin-Salvago, MD; Martinez-Martos, JM

Redox status in the sentinel lymph node of women with breast cancer

UPSALA JOURNAL OF MEDICAL SCIENCES, 2017;

FI:2,389; Q1

Torrecillas-Martinez, L; Galindo-Moreno, P; Avila-Ortiz, G; Ortega-Oller, I; Monje, A; Hernandez-Cortes, P; Aguilar, D; O'Valle, F

Significance of the Immunohistochemical Expression of Bone Morphogenetic Protein-4 in Bone Maturation after Maxillary Sinus Grafting in Humans

CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH, 2016;

FI:4,152; D1

Schuldt, M; Rubio, A; Preda, O; Nogales, FF

GATA binding protein 3 expression is present in primitive patterns of yolk sac tumours but is not expressed by differentiated variants

HISTOPATHOLOGY, 2016;

FI:3,453; Q1

Schuldt, M; Rubio, A; Preda, O; Nogales, FF

GATA binding protein 3 expression is present in primitive patterns of yolk sac tumours but is not expressed by differentiated variants

HISTOPATHOLOGY, 2016;

FI:3,425; Q1

Nogueras-Morillas, P; Blasco-Morente, G; Espadafor-Lopez, B; Aneiros-Fernandez, J; Tercedor-Sanchez, J

Keratotic Nodule on The Heel: A Quiz

ACTA DERMATO-VENEREOLOGICA, 2016;

FI:3,72; Q1

Blasco-Morente, G; Perez-Lopez, I; Martinez-Lopez, A; Aneiros-Fernandez, J; Tercedor-Sanchez, J; Arias-Santiago, S; Latorre-Fuentes, JM

Pigmented lymph nodes in a patient with melanoma: tattoos

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2016;

FI:3,029; Q1

Diaz, A; del Romero, J; Rodriguez, C; Alastrue, I; Belda, J; Bru, FJ; Camara, MM; Junquera, ML; Sanz, I; Viloria, LJ; Gil, L; Martinez, E; Gual, F; Landa, MC; Pueyo, I; Urena, JM; Martinez, B; Varela, JA; Polo, A; Azpiri, MA; Diez, M

Effects of region of birth, educational level and age on late presentation among men who have sex with men newly diagnosed with HIV in a network of STI/HIV counselling and testing clinics in Spain

EUROSURVEILLANCE, 2015;

FI:5,722; D1

Gomez-Rio, M; Dardel, NT; Chinchilla, AS; Rodriguez-Fernandez, A; Granados, GO; Caro, RL; Herrera, MZ; Santos, CEC; Lardelli-Claret, P; Llamas-Elvira, JM

F-18-Fluorocholine PET/CT as a complementary tool in the follow-up of low-grade glioma: diagnostic accuracy and clinical utility

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2015;

FI:5,383; D1

Gil-Montoya, JA; Sanchez-Lara, I; Carnero-Pardo, C; Fornieles, F; Montes, J; Vilchez, R; Burgos, JS; Gonzalez-Moles, MA; Barrios, R; Bravo, M

Is Periodontitis a Risk Factor for Cognitive Impairment and Dementia? A Case-Control Study

JOURNAL OF PERIODONTOLOGY, 2015;

FI:2,706; Q1

Barrios, R; Bravo, M; Gil-Montoya, JA; Martinez-Lara, I; Garcia-Medina, B; Tsakos, G

Oral and general health-related quality of life in patients treated for oral cancer compared to control group

HEALTH AND QUALITY OF LIFE OUTCOMES, 2015;

FI:2,12; Q1

Hidalgo-Tenorio, C; Rivero-Rodriguez, M; Gil-Anguita, C; Esquivias, J; Lopez-Castro, R; Ramirez-Taboada, J; de Hierro, ML; Lopez-Ruiz, MA; Martinez, RJ; Llano, JP