MP15-Enfermedades Hepáticas y Cáncer Colorrectal

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Ensayos clínicos

Grupo multidisciplinar integrado por investigadores clínicos (especialistas en Digestivo, Oncología Radioterápica y Cirugía General y del Aparato Digestivo) e investigadores básicos orientados hacia el estudio de las enfermedades hepáticas asociadas a obesidad y del cáncer hepático y colorrectal.

Líneas de investigación

Aplicación de la nanotecnología a la fabricación de librerías de secuenciación masiva con reducción de costo y sesgos, análisis de miRNAs circulantes con reducción de costo e incremento de eficiencia y mejora de la citometría de flujo aplicada a tejido
Células madre cancerosas en relación con el nicho tumoral en cáncer colorrectal y hepático
Desarrollo de nuevos tratamientos para el cáncer
Evasión inmune del cáncer
Fisiopatología del estrés oxidativo
Obesidad: Análisis de las poblaciones celulares de tejido adiposo en relación a la enfermedad de hígado graso en obesidad mórbida
Función inmunitaria de tejido adiposo y su implicación en el desarrollo de diabetes mellitus tipo 2 y otras patologías asociadas a obesidad
Memoria inmunitaria en infecciones virales: hepatitis C y B, citomegalovirus y SARS-CoV-2

Palabras clave

Obesidad, diabetes, EHGNA, cáncer stem cells, nicho tumoral, ROS/RNS, nanotecnología

JOSE DAVID PUENTES PARDO

ORCID

ADELINA GARCIA ROBLES

DAVID LOPEZ PEREZ

ORCID

ALICIA MARTIN-LAGOS MALDONADO

ANA GILA MEDINA

CRISTINA GONZALEZ PUGA

JOSEFA LEON LOPEZ

FRANCISCO DAVID MARTIN OLIVA

SANDRA MARIA MARTIN GUERRERO

ORCID

MARIA DEL PILAR MARTINEZ TIRADO

ANAIS REDRUELLO ROMERO

ORCID

JULIA ESCUDERO FELIU

ORCID

Inventores: Javier Salmerón;Angeles Ruiz Extremera;Esther Pavón;Paloma Muñoz de Rueda;Jose Antonio Muñoz Gámez;Rosa Quiles Pérez;Angel Carazo Gallego;Ana Gila Medina;Ana Belén Marín Álvarez;Sergio Manuel Jiménez Ruiz;Josefa León López;Jorge Casado Ruiz
Título: Método de obtención de datos útiles para predecir o pronosticar la transmisión vertical, la cronificación y/o el aclaramiento del virus de la hepatitis C.
Código: PCT/ES2016/07115

Inventores: Ángeles Ruiz Extremera;Esther J. Pavón Castillero;Javier Salmerón Escobar;Paloma Muñoz de Rueda;José Antonio Muñoz Gámez;Jorge Casado Ruiz;Ángel Carazo Gallego;Rosa Quiles Pérez;Ana Gila Medina;Josefa León López;Ana B Martín Álvarez;Sergio Manuel Jim
Título: Método de obtención de datos útiles para predecir o pronosticar la transmisión vertical del virus de la hepatitis C
Código: P201530221

Inventores: Ángeles Ruiz Extremera;Esther J. Pavón Castillero;Javier Salmerón Escobar;Paloma Muñoz de Rueda;José Antonio Muñoz Gámez;Jorge Casado Ruiz;Ángel Carazo Gallego;Rosa Quiles Pérez;Ana Gila Medina;Josefa León López;Ana B Martín Álvarez;Sergio Manuel Jim
Título: Método de obtención de datos útiles para predecir o pronosticar la cronificación de la hepatitis C y el aclaramiento del VHC
Código: P201530222

Inventores: MIGUEL ANGEL LOPEZ NEVOT,JOSEFA LEON LOPEZ,ANA GILA MEDINA,JOSÉ ANTONIO MUÑOZ GÁMEZ,ROSA QUILES PÉREZ,PALOMA MUÑOZ DE RUEDA,ÁNGEL CARAZO GALLEGO,ESTHER JOSÉ PAVÓN CASTILLERO,ANA BELÉN MARTÍN ÁLVAREZ,FCO JAVIER SALMERON ESCOBAR
Título: POLIMORFISMOS PARA PREDECIR O PRONOSTICAR LA RESPUESTA AL TRATAMIENTO ANTIVIRAL
Código: P201430205

Inventores: JAVIER SALMERÓN ESCOBAR;PALOMA MUÑOZ DE RUEDA;ROSA QUILES PÉREZ;JOSE ANTONIO MUÑOZ GAMEZ;ESTHER JOSÉ PAVÓN CASTILLERO;ANA GILA MEDINA;MIGUEL ANGEL LOPEZ NEVOT;JORGE CASADO RUIZ;ANGELES RUIZ EXTREMERA;ANA BELÉN MARTÍN;ANGEL CARAZO GALLEGO;JOSEFA LEÓN
Título: Mutaciones específicas (L5P; L7P; L15S) en el epítopo inmunodominante VHC-NS3 (aa 1253-1272) frente al HLA-DQB1*0301 provocan una no respuesta al tratamiento antiviral con pegIFN/RBV en pacientes con Hepatitis Crónica C genotipo
Código: P-06781

Garzon-Furne, AI; Ferreiro-Marzala, A; Rodriguez-Serrano, F; Esteban-Molina, M; Garcia-Orta, R; Moreno-Escobar, E; Garcia-Delgado, M; Sevilla-Martinez, M; Gomez-Luque, JM; Ocete-Hita, E; Rodríguez-Vázquez del Rey, MD; Nuila-Durán, LM; Garrido, JM

Valve repair in mitral endocarditis

CIRUGIA CARDIOVASCULAR, 2023;

Peinado, FM; Olivas-Martínez, A; Iribarne-Durán, LM; Ubiña, A; León, J; Vela-Soria, F; Fernández-Parra, J; Fernández, MF; Olea, N; Freire, C; Ocón-Hernández, O; Artacho-Cordón, F

Cell cycle, apoptosis, cell differentiation, and lipid metabolism gene expression in endometriotic tissue and exposure to parabens and benzophenones

SCIENCE OF THE TOTAL ENVIRONMENT, 2023;

FI:9,8; D1

Redruello-Romero, A; Benitez-Cantos, MS; Lopez-Perez, D; García-Rubio, J; Tamayo, F; Pérez-Bartivas, D; Moreno-SanJuan, S; Ruiz-Palmero, I; Puentes-Pardo, JD; Vilchez, JR; López-Nevot, MA; García, F; Cano, C; León, J; Carazo, A

Human adipose tissue as a major reservoir of cytomegalovirus-reactive T cells

FRONTIERS IN IMMUNOLOGY, 2023;

FI:7,3; Q1

Peinado, FM; Olivas-Martínez, A; Lendínez, I; Iribarne-Durán, LM; León, J; Fernández, MF; Sotelo, R; Vela-Soria, F; Olea, N; Freire, C; Ocón-Hernández, O; Artacho-Cordón, F

Expression Profiles of Genes Related to Development and Progression of Endometriosis and Their Association with Paraben and Benzophenone Exposure

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023;

FI:5,6; Q1

Urrutia-Maldonado, E; Alés-Palmer, M; De Rueda, PM; Peláez-Pleguezuelos, I; Ocete-Hita, E

The relation between activator and inhibitor killer-cell immunoglobulin-like receptors and hepatotoxicity in oncological treatment

MINERVA PEDIATRICS, 2023;

FI:2,6; Q2

Lopez-Perez, D; Redruello-Romero, A; Garcia-Rubio, J; Arana, C; Garcia-Escudero, LA; Tamayo, F; Salmeron, J; Galvez, J; Leon, J; Carazo, A

In Obese Patients With Type 2 Diabetes, Mast Cells in Omental Adipose Tissue Decrease the Surface Expression of CD45, CD117, CD203c, and Fc epsilon RI

FRONTIERS IN ENDOCRINOLOGY, 2022;

FI:6,055; Q1

Cuadros, MA; Sepulveda, MR; Martin-Oliva, D; Marin-Teva, JL; Neubrand, VE

Microglia and Microglia-Like Cells: Similar but Different

FRONTIERS IN CELLULAR NEUROSCIENCE, 2022;

FI:6,147; Q1

Sanchez-Castillo, AI; Sepulveda, MR; Marin-Teva, JL; Cuadros, MA; Martin-Oliva, D; Gonzalez-Rey, E; Delgado, M; Neubrand, VE

Switching Roles: Beneficial Effects of Adipose Tissue-Derived Mesenchymal Stem Cells on Microglia and Their Implication in Neurodegenerative Diseases

BIOMOLECULES, 2022;

FI:6,064; Q2

Regalado, SP; Leon, J; Feriche, B

Therapeutic approach for digestive system cancers and potential implications of exercise under hypoxia condition: what little is known? a narrative review

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2022;

FI:4,322; Q2

Perez, RF; Sanfiel, JR; Lopez, PD; Rubio, JG

Wandering liver as a cause of intestinal obstruction

GASTROENTEROLOGIA Y HEPATOLOGIA, 2022;

FI:5,867; Q2

Mustieles, V; Perez-Carrascosa, FM; Leon, J; Lange, T; Bonde, JP; Gomez-Pena, C; Artacho-Cordon, F; Barrios-Rodriguez, R; Olmedo-Requena, R; Exposito, J; Jimenez-Moleon, JJ; Arrebola, JP

Adipose Tissue Redox Microenvironment as a Potential Link between Persistent Organic Pollutants and the 16-Year Incidence of Non-hormone-Dependent Cancer

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2021;

FI:9,028; D1

Galban-Velazquez, S; Esteban, J; Cakmak, G; Artacho-Cordon, F; Leon, J; Barril, J; Vela-Soria, F; Martin-Olmedo, P; Fernandez, MF; Pellin, MC; Arrebola, JP

Associations of persistent organic pollutants in human adipose tissue with retinoid levels and their relevance to the redox microenvironment..

ENVIRONMENTAL RESEARCH, 2021;

FI:6,498; D1

Peinado, FM; Ocon-Hernandez, O; Iribarne-Duran, LM; Vela-Soria, F; Ubina, A; Padilla, C; Mora, JC; Cardona, J; Leon, J; Fernandez, MF; Olea, N; Artacho-Cordon, F

Cosmetic and personal care product use, urinary levels of parabens and benzophenones, and risk of endometriosis: results from the EndEA study.

ENVIRONMENTAL RESEARCH, 2021;

FI:6,498; D1

Aroca-Siendones, MI; Moreno-SanJuan, S; Puentes-Pardo, JD; Verbeni, M; Arnedo, J; Escudero-Feliu, J; Garcia-Costela, M; Garcia-Robles, A; Carazo, A; Leon, J

Core Circadian Clock Proteins as Biomarkers of Progression in Colorectal Cancer

BIOMEDICINES, 2021;

FI:6,081; Q1

Rios-Arrabal, S; Puentes-Pardo, JD; Moreno-SanJuan, S; Szuba, A; Casado, J; Garcia-Costela, M; Escudero-Feliu, J; Verbeni, M; Cano, C; Gonzalez-Puga, C; Maldonado, AML; Carazo, A; Leon, J

Endothelin-1 as a Mediator of Heme Oxygenase-1-Induced Stemness in Colorectal Cancer: Influence of p53

JOURNAL OF PERSONALIZED MEDICINE, 2021;

FI:4,945; Q1

Martin-Guerrero, SM; Casado, P; Hijazi, M; Rajeeve, V; Plaza-Diaz, J; Abadia-Molina, F; Navascues, J; Cuadros, MA; Cutillas, PR; Martin-Oliva, D

PARP-1 activation after oxidative insult promotes energy stress-dependent phosphorylation of YAP1 and reduces cell viability

BIOCHEMICAL JOURNAL, 2020;

FI:4,097; Q2

Artacho-Cordon, F; Rios-Arrabal, S; Leon, J; Frederiksen, H; Saenz, JM; Martin-Olmedo, P; Fernandez, MF; Olea, N; Arrebola, JP

Adipose tissue concentrations of non-persistent environmental phenols and local redox balance in adults from Southern Spain

ENVIRONMENT INTERNATIONAL, 2019;

FI:7,943; D1

Leon, J; Saenz, JM; Artacho-Cordon, F; Fernandez, MF; Martin-Olmedo, P; Salamanca-Fernandez, E; Gomez-Pena, C; Olea, N; Arrebola, JP

Contribution of sociodemographic, occupational, lifestyle and dietary characteristics to the oxidative stress microenvironment in adipose tissue

ENVIRONMENTAL RESEARCH, 2019;

FI:5,026; D1

Salinas-Asensio, MM; Rios-Arrabal, S; Artacho-Cordon, F; Olivares-Urbano, MA; Calvente, I; Leon, J; Nunez, MI

Exploring the radiosensitizing potential of magnetotherapy: a pilot study in breast cancer cells

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 2019;

FI:2,266; D1

Martin-Guerrero, SM; Casado, P; Munoz-Gamez, JA; Carrasco, MC; Navascues, J; Cuadros, MA; Lopez-Gimenez, JF; Cutillas, PR; Martin-Oliva, D

Poly(ADP-Ribose) Polymerase-1 inhibition potentiates cell death and phosphorylation of DNA damage response proteins in oxidative stressed retinal cells

EXPERIMENTAL EYE RESEARCH, 2019;

FI:2,998; Q1

Morales-Santana, S; Morell, S; Leon, J; Carazo-Gallego, A; Jimenez-Lopez, JC; Morell, M

An Overview of the Polymorphisms of Circadian Genes Associated With Endocrine Cancer

FRONTIERS IN ENDOCRINOLOGY, 2019;

FI:3,634; Q2

Ampuero, J; Jimeno, C; Quiles, R; Rosales, JM; Llerena, S; Palomo, N; Cordero, P; Serrano, FJ; Urquijo, JJ; Moreno-Planas, JM; Ontanilla, G; Hernandez, M; Ortega-Alonso, A; Maraver, M; Bonacci, M; Rojas, A; Figueruela, B; Forns, X; Andrade, RJ; Calleja, JL; Diago, M; Carmona, I; de la Mata, M; Buti, M; Crespo, J; Pascasio, JM; Navarro, JM; Salmeron, J; Romero-Gomez, M

Impact of comorbidities on patient outcomes after interferon-free therapy-induced viral eradication in hepatitis C

JOURNAL OF HEPATOLOGY, 2018;

FI:15,04; D1

Garcia-Rubio, J; Leon, J; Redruello-Romero, A; Pavon, E; Cozar, A; Tamayo, F; Caba-Molina, M; Salmeron, J; Carazo, A

Cytometric analysis of adipose tissue reveals increments of adipocyte progenitor cells after weight loss induced by bariatric surgery

SCIENTIFIC REPORTS, 2018;

FI:4,122; Q1

Lima-Cabello, E; Morales-Santana, S; Leon, J; Alche, V; Clemente, A; Alche, JD; Jimenez-Lopez, JC

Narrow-leafed lupin (Lupinus angustifolius L.) seed -conglutins reverse the induced insulin resistance in pancreatic cells

FOOD & FUNCTION, 2018;

FI:3,289; Q1

Guidi, G; Casado, J; Ascasibar, Y; Garcia-Benito, R; Galbany, L; Sanchez-Blazquez, P; Sanchez, SF; Rosales-Ortega, FF; Scannapieco, C

The SELGIFS data challenge: generating synthetic observations of CALIFA galaxies from hydrodynamical simulations

MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY, 2018;

FI:5,194; Q1

de la Oliva, P; Cambra-Lasaosa, FJ; Quintana-Diaz, M; Rey-Galan, C; Sanchez-Diaz, JI; Martin-Delgado, MC; de Carlos-Vicente, JC; Hernandez-Rastrollo, R; Holanda-Pena, MS; Pilar-Orive, FJ; Ocete-Hita, E; Rodriguez-Nunez, A; Serrano-Gonzalez, A; Blanch, L

Admission, discharge and triage guidelines for paediatric intensive care units in Spain

ANALES DE PEDIATRIA, 2018;

FI:1,318; Q3

Carrillo, CF; Lens, S; Llop, E; Pascasio, JM; Crespo, J; Arenas, J; Fernandez, I; Baliellas, C; Carrion, JA; de la Mata, M; Buti, M; Castells, L; Albillos, A; Romero, M; Turnes, J; Pons, C; Moreno-Planas, JM; Moreno-Palomares, JJ; Fernandez-Rodriguez, C; Garcia-Samaniego, J; Prieto, M; Bermejo, MF; Salmeron, J; Badia, E; Salcedo, M; Herrero, JI; Granados, R; Ble, M; Marino, Z; Calleja, JL

Treatment of Hepatitis C Virus Infection in Patients With Cirrhosis and Predictive Value of Model for End-Stage Liver Disease: Analysis of Data From the Hepa-C Registry

HEPATOLOGY, 2017;

FI:13,246; D1

Martin-Guerrero, SM; Munoz-Gamez, JA; Carrasco, MC; Salmeron, J; Martin-Estebane, M; Cuadros, MA; Navascues, J; Martin-Oliva, D

Poly(ADP-ribose) polymerases inhibitors prevent early mitochondrial fragmentation and hepatocyte cell death induced by H2O2

PLOS ONE, 2017;

FI:2,806; Q1

de Rueda, PM; Jimenez-Ruiz, SM; Quiles, R; Pavon-Castillero, EJ; Munoz-Gamez, JA; Casado, J; Gila, A; Ruiz-Extremera, A; Salmeron, J

The antigenic variability of HCV in viral HLA-Ag binding is related to the activation of the host immune response

SCIENTIFIC REPORTS, 2017;

FI:4,259; Q1

Ocete-Hita, E; Salmeron-Fernandez, MJ; Urrutia-Maldonado, E; Munoz-de-Rueda, P; Salmeron-Ruiz, M; Martinez-Padilla, MC; Ruiz-Extremera, A

Analysis of Immunogenetic Factors in Idiosyncratic Drug-induced Liver Injury in the Pediatric Population

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2017;

FI:2,799; Q1

Ruiz-Extremera, A; Pavon-Castillero, EJ; Florido, M; de Rueda, PM; Munoz-Gamez, JA; Casado, J; Carazo, A; Quiles, R; Jimenez-Ruiz, SM; Gila, A; Luna, JD; Leon, J; Salmeron, J

Influence of HLA class I, HLA class II and KIRs on vertical transmission and chronicity of hepatitis C virus in children

PLOS ONE, 2017;

FI:2,806; Q1

Artacho-Cordon, F; Leon, J; Saenz, JM; Fernandez, MF; Martin-Olmedo, P; Olea, N; Arrebola, JP

Contribution of Persistent Organic Pollutant Exposure to the Adipose Tissue Oxidative Microenvironment in an Adult Cohort: A Multipollutant Approach

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2016;

FI:5,393; D1

Munoz-Gamez, JA; Salmeron, J; Ruiz-Extremera, A

Hepatitis C during pregnancy, vertical transmission and new treatment possibilities

MEDICINA CLINICA, 2016;

FI:1,267; Q2

Quer, J; Gregori, J; Rodriguez-Frias, F; Buti, M; Madejon, A; Perez-del-Pulgar, S; Garcia-Cehic, D; Casillas, R; Blasi, M; Homs, M; Tabernero, D; Alvarez-Tejado, M; Munoz, JM; Cubero, M; Caballero, A; delCampo, JA; Domingo, E; Belmonte, I; Nieto, L; Lens, S; Munoz-de-Rueda, P; Sanz-Cameno, P; Sauleda, S; Bes, M; Gomez, J; Briones, C; Perales, C; Sheldon, J; Castells, L; Viladomiu, L; Salmeron, J; Ruiz-Extremera, A; Quiles-Perez, R; Moreno-Otero, R; Lopez-Rodriguez, R; Allende, H; Romero-Gomez, M; Guardia, J; Esteban, R; Garcia-Samaniego, J; Forns, X; Esteban, JI

High-Resolution Hepatitis C Virus Subtyping Using NS5B Deep Sequencing and Phylogeny, an Alternative to Current Methods (vol 53, pg 219, 2015)

JOURNAL OF CLINICAL MICROBIOLOGY, 2016;

FI:3,631; Q2

Cabrera-Martos, I; Valenza, MC; Valenza-Demet, G; Benitez-Feliponi, A; Robles-Vizcaino, C; Ruiz-Extremera, A

Effects of manual therapy on treatment duration and motor development in infants with severe nonsynostotic plagiocephaly: a randomised controlled pilot study

CHILDS NERVOUS SYSTEM, 2016;

FI:1,08; Q3

Cabrera-Martos, I; Valenza, MC; Valenza-Demet, G; Benitez-Feliponi, A; Robles-Vizcaino, C; Ruiz-Extremera, A

Repercussions of plagiocephaly on posture, muscle flexibility and balance in children aged 3-5years old

JOURNAL OF PAEDIATRICS AND CHILD HEALTH, 2016;

FI:1,477; Q3

Munoz-Gamez, JA; Viota, JL; Barrientos, A; Carazo, A; Sanjuan-Nunez, L; Quiles-Perez, R; Munoz-de-Rueda, P; Delgado, A; Ruiz-Extremera, A; Salmeron, J

Synergistic cytotoxicity of the poly (ADP-ribose) polymerase inhibitor ABT-888 and temozolomide in dual-drug targeted magnetic nanoparticles

LIVER INTERNATIONAL, 2015;

FI:4,85; Q1

Quer, J; Gregori, C; Rodriguez-Frias, F; Buti, M; Madejon, A; Perez-del-Pulgar, S; Garcia-Cehic, D; Casillas, R; Blasi, M; Homs, M; Tabernero, D; Alvarez-Tejado, M; Munoz, JM; Cubero, M; Caballero, A; delcampo, JA; Domingo, E; Belmonte, I; Nieto, L; Lens, S; Munoz-de-Rueda, P; Sanz-Cameno, P; Sauleda, S; Bes, M; Gomez, J; Briones, C; Perales, C; Sheldon, J; Castells, L; Viladomiu, L; Salmeron, J; Ruiz-Extremera, A; Quiles-Perez, R; Moreno-Otero, R; Lopez-Rodriguez, R; Allende, H; Romero-Gomez, M; Guardia, J; Esteban, R; Garcia-Samaniego, J; Forns, X; Esteban, JI

High-Resolution Hepatitis C Virus Subtyping Using NS5B Deep Sequencing and Phylogeny, an Alternative to Current Methods

JOURNAL OF CLINICAL MICROBIOLOGY, 2015;

FI:3,993; Q1

Artacho-Cordon, F; Rios-Arrabal, S; Olivares-Urbano, MA; Storch, K; Dickreuter, E; Munoz-Gamez, JA; Leon, J; Calvente, I; Torne, P; Salinas, MD; Cordes, N; Nunez, MI

Valproic acid modulates radiation-enhanced matrix metalloproteinase activity and invasion of breast cancer cells

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 2015;

FI:1,687; Q1

Ampuero, J; del Campo, JA; Rojas, L; Garcia-Lozano, RJ; Buti, M; Sola, R; Forns, X; Moreno-Otero, R; Andrade, R; Diago, M; Salmeron, J; Rodrigo, L; Pons, JA; Navarro, JM; Calleja, JL; Garcia-Samaniego, J; Garcia-Valdecasas, M; Rojas, A; Millan, R; Gonzalez-Escribano, MF; Romero-Gomez, M

Fine-mapping butyrophilin family genes revealed several polymorphisms influencing viral genotype selection in hepatitis C infection

GENES AND IMMUNITY, 2015;

FI:2,913; Q2

Salmeron, J; Vinaixa, C; Berenguer, R; Pascasio, JM; Ruano, JJS; Serra, MA; Gila, A; Diago, M; Romero-Gomez, M; Navarro, JM; Testillano, M; Fernandez, C; Espinosa, D; Carmona, I; Pons, JA; Jorquera, F; Rodriguez, FJ; Perez, R; Montero, JL; Granados, R; Fernandez, M; Martin, AB; de Rueda, PM; Quiles, R