MP02-Farmacología Cardiovascular

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Nuestras líneas de investigación tienen como objetivos generales: estudiar el papel del sistema inmune en la disfunción endotelial en hipertensión, buscar estrategias de modulación de la flora intestinal y su impacto integral en el control de la presión arterial. En ambos casos colaboramos con el Hospital Universitario Virgen de la Nieves de Granada y con empresas como Biosearch SA y con el Centro Tecnológico de Investigación y Desarrollo del Alimento Funcional (CIDAF).

JUAN MANUEL DUARTE PEREZ

MANUEL GOMEZ GUZMAN

ROSARIO JIMENEZ MOLEON

MIGUEL ROMERO PEREZ

MANUEL SANCHEZ SANTOS

Lopez-Carmona, F; Toro-Ruiz, A; Gomez-Guzman, M; Valverde-Merino, MI; Piquer-Martinez, C; Zarzuelo, MJ

Community pharmacy is the key to improving vitamin D levels

EXPLORATORY RESEARCH IN CLINICAL AND SOCIAL PHARMACY, 2023;

Moleón, J; González-Correa, C; Miñano, S; Robles-Vera, I; de la Visitación, N; Barranco, AM; Gómez-Guzmán, M; Sánchez, M; Riesco, P; Guerra-Hernández, E; Toral, M; Romero, M; Duarte, J

Protective effect of microbiota-derived short chain fatty acids on vascular dysfunction in mice with systemic lupus erythematosus induced by toll like receptor 7 activation

PHARMACOLOGICAL RESEARCH, 2023;

FI:9,3; D1

Moleón, J; González-Correa, C; Robles-Vera, I; Miñano, S; de la Visitación, N; Barranco, AM; Martín-Morales, N; O'Valle, F; Mayo-Martínez, L; García, A; Toral, M; Jiménez, R; Romero, M; Duarte, J

Targeting the gut microbiota with dietary fibers: a novel approach to prevent the development cardiovascular complications linked to systemic lupus erythematosus in a preclinical study

GUT MICROBES, 2023;

FI:12,2; D1

González-Correa, C; Moleón, J; Miñano, S; Robles-Vera, I; Toral, M; Martín-Morales, N; O'Valle, F; Sánchez, M; Gómez-Guzmán, M; Jiménez, R; Romero, M; Duarte, J

Mineralocorticoid receptor blockade improved gut microbiota dysbiosis by reducing gut sympathetic tone in spontaneously hypertensive rats

BIOMEDICINE & PHARMACOTHERAPY, 2023;

FI:7,5; Q1

Romero, M; Duarte, J

Probiotics and Prebiotics in Cardiovascular Diseases

NUTRIENTS, 2023;

FI:5,9; Q1

Dichiara, M; Artacho-Cordon, A; Turnaturi, R; Santos-Caballero, M; Gonzalez-Cano, R; Pasquinucci, L; Barbaraci, C; Rodriguez-Gomez, I; Gomez-Guzman, M; Marrazzo, A; Cobos, EJ; Amata, E

Dual Sigma-1 receptor antagonists and hydrogen sulfide-releasing compounds for pain treatment: Design, synthesis, and pharmacological evaluation

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022;

FI:7,088; D1

Dichiara, M; Artacho-Cordon, A; Turnaturi, R; Santos-Caballero, M; Gonzalez-Cano, R; Pasquinucci, L; Barbaraci, C; Rodriguez-Gomez, I; Gomez-Guzman, M; Marrazzo, A; Cobos, EJ; Amata, E

Dual Sigma-1 receptor antagonists and hydrogen sulfide-releasing compounds for pain treatment: Design, synthesis, and pharmacological evaluation.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022;

FI:7,088; D1

Ruiz-Malagon, AJ; Rodriguez-Sojo, MJ; Hidalgo-Garcia, L; Molina-Tijeras, JA; Garcia, F; Pischel, I; Romero, M; Duarte, J; Diez-Echave, P; Rodriguez-Cabezas, ME; Rodriguez-Nogales, A; Galvez, J

The Antioxidant Activity of Thymus serpyllum Extract Protects against the Inflammatory State and Modulates Gut Dysbiosis in Diet-Induced Obesity in Mice.

ANTIOXIDANTS, 2022;

FI:7,675; D1

Diez-Echave, P; Vezza, T; Algieri, F; Ruiz-Malagon, AJ; Hidalgo-Garcia, L; Garcia, F; Moron, R; Sanchez, M; Toral, M; Romero, M; Duarte, J; Garrido-Mesa, J; Rodriguez-Cabezas, ME; Rodriguez-Nogales, A; Galvez, J

The melatonergic agonist agomelatine ameliorates high fat diet-induced obesity in mice through the modulation of the gut microbiome.

BIOMEDICINE & PHARMACOTHERAPY, 2022;

FI:7,419; D1

Gonzalez-Correa, C; Moleon, J; Minano, S; de la Visitacion, N; Robles-Vera, I; Gomez-Guzman, M; Jimenez, R; Romero, M; Duarte, J

Trimethylamine N-Oxide Promotes Autoimmunity and a Loss of Vascular Function in Toll-like Receptor 7-Driven Lupus Mice

ANTIOXIDANTS, 2022;

FI:7,675; D1

de la Visitacion, N; Robles-Vera, I; Toral, M; Gomez-Guzman, M; Sanchez, M; Moleon, J; Gonzalez-Correa, C; Martin-Morales, N; O'Valle, F; Jimenez, RC; Romero, M; Duarte, J

Gut microbiota contributes to the development of hypertension in a genetic mouse model of systemic lupus erythematosus

BRITISH JOURNAL OF PHARMACOLOGY, 2021;

FI:8,74; D1

de la Visitacion, N; Robles-Vera, I; Moleon, J; Gonzalez-Correa, C; Aguilera-Sanchez, N; Toral, M; Gomez-Guzman, M; Sanchez, M; Jimenez, R; Martin-Morales, N; O'Valle, F; Romero, M; Duarte, J

Gut Microbiota Has a Crucial Role in the Development of Hypertension and Vascular Dysfunction in Toll-like Receptor 7-Driven Lupus Autoimmunity

ANTIOXIDANTS, 2021;

FI:6,313; D1

Vezza, T; Garrido-Mesa, J; Diez-Echave, P; Hidalgo-Garcia, L; Ruiz-Malagon, AJ; Garcia, F; Sanchez, M; Toral, M; Romero, M; Duarte, J; Guillamon, E; Banos, A; Moron, R; Galvez, J; Rodriguez-Nogales, A; Rodriguez-Cabezas, ME

Allium-Derived Compound Propyl Propane Thiosulfonate (PTSO) Attenuates Metabolic Alterations in Mice Fed a High-Fat Diet through Its Anti-Inflammatory and Prebiotic Properties

NUTRIENTS, 2021;

FI:5,719; Q1

Robles-Vera, I; de la Visitacion, N; Toral, M; Sanchez, M; Romero, M; Gomez-Guzman, M; Vargas, F; Duarte, J; Jimenez, R

Changes in Gut Microbiota Induced by Doxycycline Influence in Vascular Function and Development of Hypertension in DOCA-Salt Rats

NUTRIENTS, 2021;

FI:5,719; Q1

Almazan, MM; Pozo, JFM; Perez, JMD

EVALUATION OF DOCETAXEL USE IN NON-SMALL CELL LUNG CANCER: REAL-WORLD HEALTH OUTCOMES

FARMACIA, 2021;

FI:1,433; Q4

Robles-Vera, I; Toral, M; de la Visitacion, N; Sanchez, M; Gomez-Guzman, M; Munoz, R; Algieri, F; Vezza, T; Jimenez, R; Galvez, J; Romero, M; Redondo, JM; Duarte, J

Changes to the gut microbiota induced by losartan contributes to its antihypertensive effects

BRITISH JOURNAL OF PHARMACOLOGY, 2020;

FI:7,73; D1

Alcaide-Hidalgo, JM; Romero, M; Duarte, J; Lopez-Huertas, E

Antihypertensive Effects of Virgin Olive Oil (Unfiltered) Low Molecular Weight Peptides with ACE Inhibitory Activity in Spontaneously Hypertensive Rats

NUTRIENTS, 2020;

FI:4,546; Q1

Martinez-Oca, P; Robles-Vera, I; Sanchez-Roncero, A; Escriva, F; Perez-Vizcaino, F; Duarte, J; Alvarez, C; Fernandez-Millan, E

Gut DYSBIOSIS and altered barrier function precedes the appearance of metabolic syndrome in a rat model of nutrient-induced catch-up growth

JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2020;

FI:4,873; Q1

Callejo, M; Barbera, JA; Duarte, J; Perez-Vizcaino, F

Impact of Nutrition on Pulmonary Arterial Hypertension

NUTRIENTS, 2020;

FI:4,546; Q1

de la Visitacion, N; Robles-Vera, I; Toral, M; O'Valle, F; Moleon, J; Gomez-Guzman, M; Romero, M; Duarte, M; Sanchez, M; Jimenez, R; Duarte, J

Lactobacillus fermentumCECT5716 prevents renal damage in the NZBWF1 mouse model of systemic lupus erythematosus

FOOD & FUNCTION, 2020;

FI:4,171; Q1

Toral, M; Robles-Vera, I; de la Visitacion, N; Romero, M; Sanchez, M; Gomez-Guzman, M; Rodriguez-Nogales, A; Yang, T; Jimenez, R; Algieri, F; Galvez, J; Raizada, MK; Duarte, J

Role of the immune system in vascular function and blood pressure control induced by faecal microbiota transplantation in rats

ACTA PHYSIOLOGICA, 2019;

FI:5,868; D1

Toral, M; Robles-Vera, I; Romero, M; de la Visitacion, N; Sanchez, M; O'Valle, F; Rodriguez-Nogales, A; Galvez, J; Duarte, J; Jimenez, R

Lactobacillus fermentum CECT5716: a novel alternative for the prevention of vascular disorders in a mouse model of systemic lupus erythematosus

FASEB JOURNAL, 2019;

FI:5,391; D1

Hidalgo-Gutierrez, A; Barriocanal-Casado, E; Bakkali, M; Diaz-Casado, ME; Sanchez-Maldonado, L; Romero, M; Sayed, RK; Prehn, C; Escames, G; Duarte, J; Acuna-Castroviejo, D; Lopez, LC

beta-RA reduces DMQ/CoQ ratio and rescues the encephalopathic phenotype in Coq9(R239X) mice

EMBO MOLECULAR MEDICINE, 2019;

FI:10,624; D1

de la Visitacion, N; Robles-Vera, I; Toral, M; Duarte, J

Protective Effects of Probiotic Consumption in Cardiovascular Disease in Systemic Lupus Erythematosus

NUTRIENTS, 2019;

FI:4,171; Q1

Sanchez, M; Romero, M; Gomez-Guzman, M; Tamargo, J; Perez-Vizcaino, F; Duarte, J

Cardiovascular Effects of Flavonoids

CURRENT MEDICINAL CHEMISTRY, 2019;

FI:3,894; Q1

Toral, M; Romero, M; Rodriguez-Nogales, A; Jimenez, R; Robles-Vera, I; Algieri, F; Chueca-Porcuna, N; Sanchez, M; de la Visitacion, N; Olivares, M; Garcia, F; Perez-Vizcaino, F; Galvez, J; Duarte, J

Lactobacillus fermentum Improves Tacrolimus-Induced Hypertension by Restoring Vascular Redox State and Improving eNOS Coupling

MOLECULAR NUTRITION & FOOD RESEARCH, 2018;

FI:5,151; D1

Robles-Vera, I; Toral, M; de la Visitacion, N; Sanchez, M; Romero, M; Olivares, M; Jimenez, R; Duarte, J

The Probiotic Lactobacillus fermentum Prevents Dysbiosis and Vascular Oxidative Stress in Rats with Hypertension Induced by Chronic Nitric Oxide Blockade

MOLECULAR NUTRITION & FOOD RESEARCH, 2018;

FI:5,151; D1

Callejo, M; Mondejar-Parreno, G; Barreira, B; Izquierdo-Garcia, JL; Morales-Cano, D; Esquivel-Ruiz, S; Moreno, L; Cogolludo, A; Duarte, J; Perez-Vizcaino, F

Pulmonary Arterial Hypertension Affects the Rat Gut Microbiome

SCIENTIFIC REPORTS, 2018;

FI:4,122; Q1

Jimenez, R; Toral, M; Gomez-Guzman, M; Romero, M; Sanchez, M; Mahmoud, AM; Duarte, J

The Role of Nrf2 Signaling in PPAR beta/delta-Mediated Vascular Protection against Hyperglycemia-Induced Oxidative Stress

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2018;

FI:4,936; Q2

Arias, F; Camacho, ME; Carrion, MD; Chayah, M; Romero, M; Duarte, J; Gallo, MA

Thiadiazoline- and Pyrazoline-Based Carboxamides and Carbothioamides: Synthesis and Inhibition against Nitric Oxide Synthase

JOURNAL OF CHEMISTRY, 2018;

FI:1,726; Q3

Romero, M; Toral, M; Robles-Vera, I; Sanchez, M; Jimenez, R; O'Valle, F; Rodriguez-Nogales, A; Perez-Vizcaino, F; Galvez, J; Duarte, J

Activation of Peroxisome Proliferator Activator Receptor / Improves Endothelial Dysfunction and Protects Kidney in Murine Lupus

HYPERTENSION, 2017;

FI:6,857; D1

Luna-Sanchez, M; Hidalgo-Gutierrez, A; Hildebrandt, TM; Chaves-Serrano, J; Barriocanal-Casado, E; Santos-Fandila, A; Romero, M; Sayed, RKA; Duarte, J; Prokisch, H; Schuelke, M; Distelmaier, F; Escames, G; Acuna-Castroviejo, D; Lopez, LC

CoQ deficiency causes disruption of mitochondrial sulfide oxidation, a new pathomechanism associated with this syndrome

EMBO MOLECULAR MEDICINE, 2017;

FI:9,249; D1

Mahmoud, AM; Wilkinson, FL; McCarthy, EM; Moreno-Martinez, D; Langford-Smith, A; Romero, M; Duarte, J; Alexander, MY

Endothelial microparticles prevent lipid-induced endothelial damage via Akt/eNOS signaling and reduced oxidative stress

FASEB JOURNAL, 2017;

FI:5,498; D1

Romero, M; Vera, B; Galisteo, M; Toral, M; Galvez, J; Perez-Vizcaino, F; Duarte, J

Protective vascular effects of quercitrin in acute TNBS-colitis in rats: the role of nitric oxide

FOOD & FUNCTION, 2017;

FI:3,247; Q1

Toral, M; Jimenez, R; Romero, M; Robles-Vera, I; Sanchez, M; Salaices, M; Sabio, JM; Duarte, J

Role of endoplasmic reticulum stress in the protective effects of PPAR beta/delta activation on endothelial dysfunction induced by plasma from patients with lupus

ARTHRITIS RESEARCH & THERAPY, 2017;

FI:4,121; Q1

Toral, M; Romero, M; Jimenez, R; Robles-Vera, I; Tamargo, J; Martinez, MC; Perez-Vizcaino, F; Duarte, J

Role of UCP2 in the protective effects of PPAR beta/delta activation on lipopolysaccharide-induced endothelial dysfunction

BIOCHEMICAL PHARMACOLOGY, 2016;

FI:5,091; D1

Romero, M; Leon-Gomez, E; Lobysheva, I; Rath, G; Dogne, JM; Feron, O; Dessy, C

Effects of BM-573 on Endothelial Dependent Relaxation and Increased Blood Pressure at Early Stages of Atherosclerosis

PLOS ONE, 2016;

FI:3,057; Q1

Romero, M; Toral, M; Gomez-Guzman, M; Jimenez, R; Galindo, P; Sanchez, M; Olivares, M; Galvez, J; Duarte, J

Antihypertensive effects of oleuropein-enriched olive leaf extract in spontaneously hypertensive rats

FOOD & FUNCTION, 2016;

FI:2,686; Q1

Morales-Cano, D; Moreno, L; Barreira, B; Briones, AM; Pandolfi, R; Moral-Sanz, J; Callejo, M; Mondejar-Parreno, G; Cortijo, J; Salaices, M; Duarte, J; Perez-Vizcaino, F; Cogolludo, A

Activation of PPAR beta/delta prevents hyperglycaemia-induced impairment of Kv7 channels and cAMP-mediated relaxation in rat coronary arteries

CLINICAL SCIENCE, 2016;

FI:5,016; Q1

Chamorro, V; Pandolfi, R; Moreno, L; Barreira, B; Martinez-Ramas, A; Morales-Cano, D; Ruiz-Cabello, J; Lorente, JA; Duarte, J; Cogolludo, A; Alvarez-Sala, JL; Perez-Vizcaino, F

Effects of Quercetin in a Rat Model of Hemorrhagic Traumatic Shock and Reperfusion

MOLECULES, 2016;

FI:2,465; Q2

Gomez-Guzman, M; Toral, M; Romero, M; Jimenez, R; Galindo, P; Sanchez, M; Zarzuelo, MJ; Olivares, M; Galvez, J; Duarte, J

Antihypertensive effects of probiotics Lactobacillus strains in spontaneously hypertensive rats

MOLECULAR NUTRITION & FOOD RESEARCH, 2015;

FI:4,603; D1

Morales-Cano, D; Moreno, L; Barreira, B; Pandolfi, R; Chamorro, V; Jimenez, R; Villamor, E; Duarte, J; Perez-Vizcaino, F; Cogolludo, A

Kv7 channels critically determine coronary artery reactivity: left-right differences and down-regulation by hyperglycaemia

CARDIOVASCULAR RESEARCH, 2015;

FI:5,94; D1

Tamargo, J; Duarte, J; Ruilope, LM

New Antihypertensive Drugs Under Development

CURRENT MEDICINAL CHEMISTRY, 2015;

FI:3,853; D1

Blázquez-Medela AM, García-Sánchez O, Quirós Y, Blanco-Gozalo V, Prieto-García L, Sancho-Martínez SM, Romero M, Duarte JM, López-Hernández FJ, López-Novoa JM, Martínez-Salgado C.

Increased Klk9 Urinary Excretion Is Associated to Hypertension-Induced Cardiovascular Damage and Renal Alterations

MEDICINE, 2015;

FI:5,723; D1

Toral, M; Romero, M; Jimenez, R; Mahmoud, AM; Barroso, E; Gomez-Guzman, M; Sanchez, M; Cogolludo, A; Garcia-Redondo, AB; Briones, AM; Vazquez-Carrera, M; Perez-Vizcaino, F; Duarte, J