A09-Genética y Oncología Molecular

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El Grupo A-09 del Instituto de Investigación Biosanitaria de Granada, está centrado en oncología molecular, en el estudio de las bases moleculares y perfiles de expresión génica en cáncer. En nuestro grupo pretendemos el estudio genético de los tumores, en concreto estamos centrados en cáncer de pulmón. La comprensión de las características genéticas y de la biología del tumor es importante porque puede permitir encontrar genes alterados y proteínas alteradas en tipos tumorales específicos que puedan ser utilizados como biomarcadores y dianas para el desarrollo de nuevas terapias del que se puedan beneficiar los pacientes de cáncer de pulmón. Por otro lado, el grupo de investigación está también enfocado hacia el estudio de nuevos compuestos farmacológicos con actividad antitumoral dirigidos frente a nuevas dianas terapéuticas.

Palabras clave

Cáncer de pulmón de células no pequeñas; Adenocarcinoma; Cáncer escamoso de pulmón; Biomarcadores; Dianas terapéuticas; Fármacos antitumorales.

CLAUDIA TESO PEREZ

ABEL SANCHEZ-PALENCIA RAMOS

Jimenez-Carretero, M; Rodríguez-López, J; Ropero-Moreno, C; Granada, J; Delgado-Martín, J; Martinez-Bueno, M; Fernandez-Vivas, A; Jimenez-Lopez, C

Biomimetic magnetic nanoparticles for bacterial magnetic concentration in liquids and qPCR-detection

FOOD CONTROL, 2023;

FI:6; Q1

García-López, JD; Teso-Pérez, C; Martín-Platero, AM; Peralta-Sánchez, JM; Fonollá-Joya, J; Martínez-Bueno, M; Baños, A

Lactiplantibacillus paraplantarum BPF2 and Pediococcus acidilactici ST6, Two Bacteriocinogenic Isolated Strains from Andalusian Spontaneous Fermented Sausages

FOODS, 2023;

FI:5,2; Q1

Cebrián, R; Martínez-García, M; Fernández, M; García, F; Martfíez-Bueno, M; Valdivia, E; Kuipers, OP; Montalbán-López, M; Maqueda, M

Advances in the preclinical characterization of the antimicrobial peptide AS-48

FRONTIERS IN MICROBIOLOGY, 2023;

FI:5,2; Q2

Teso-Perez, C; Martinez-Bueno, M; Sánchez, JMP; Valdivia, E; Fárez-Vidal, ME; Martín-Platero, AM

Circular and L50-like leaderless enterocins share a common ABC-transporter immunity gene

BMC GENOMICS, 2023;

FI:4,4; Q2

Rabelo-Ruiz, M; Peralta-Sánchez, JM; Martín-Platero, AM; Ruiz, AJ; Agraso, MD; Bermúdez, L; Ariza, JJ; Baños, A; Valdivia, E; Martínez-Bueno, M

Allium-Derived Compound Propyl Propane Thiosulfonate (PTSO) Reduces Vibrio Populations and Increases Body Weight of European Seabass (Dicentrarchus labrax) Juveniles

ANTIBIOTICS-BASEL, 2023;

FI:4,8; Q2

Boyero, L; Martin-Padron, J; Farez-Vidal, ME; Rodriguez, MI; Andrades, A; Peinado, P; Arenas, AM; Ritore-Salazar, F; Alvarez-Perez, JC; Cuadros, M; Medina, PP

PKP1 and MYC create a feedforward loop linking transcription and translation in squamous cell lung cancer.

CELLULAR ONCOLOGY, 2022;

FI:7,051; Q1

Santofimia-Castano, P; Rizzuti, B; Pey, AL; Farez-Vidal, ME; Iovanna, JL; Neira, JL

Intrinsically disordered protein NUPR1 binds to the armadillo-repeat domain of Plakophilin 1

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2021;

FI:6,953; D1

Teso-Perez, C; Martinez-Bueno, M; Peralta-Sanchez, JM; Valdivia, E; Maqueda, M; Farez-Vidal, ME; Martin-Platero, AM

Enterocin Cross-Resistance Mediated by ABC Transport Systems

MICROORGANISMS, 2021;

FI:4,128; Q2

Neira, JL; Rizzuti, B; Ortega-Alarcon, D; Giudici, AM; Abian, O; Farez-Vidal, ME; Velazquez-Campoy, A

The armadillo-repeat domain of plakophilin 1 binds the C-terminal sterile alpha motif (SAM) of p73

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2021;

FI:3,77; Q2

Martin-Padron, J; Boyero, L; Rodriguez, MI; Andrades, A; Diaz-Cano, I; Peinado, P; Balinas-Gavira, C; Alvarez-Perez, JC; Coira, IF; Farez-Vidal, ME; Medina, PP

Plakophilin 1 enhances MYC translation, promoting squamous cell lung cancer

ONCOGENE, 2020;

FI:7,971; D1

Gomez-Llorente, MA; Martinez-Canavate, A; Chueca, N; Rico, MD; Romero, R; Anguita-Ruiz, A; Aguilera, CM; Gil-Campos, M; Mesa, MD; Khakimov, B; Morillo, JA; Gil, A; Camacho, J; Gomez-Llorente, C

A Multi-Omics Approach Reveals New Signatures in Obese Allergic Asthmatic Children

BIOMEDICINES, 2020;

FI:4,717; Q1

Giudici, AM; Hernandez-Cifre, JG; Camara-Artigas, A; Hornos, F; Martinez-Rodriguez, S; Alvarez-Perez, JC; Diaz-Cano, I; Farez-Vidal, ME; Neira, JL

The isolated armadillo-repeat domain of Plakophilin 1 is a monomer in solution with a low conformational stability

JOURNAL OF STRUCTURAL BIOLOGY, 2020;

FI:3,071; Q2

Galindo, I; Gomez-Morales, M; Diaz-Cano, I; Andrades, A; Caba-Molina, M; Miranda-Leon, MT; Medina, PP; Martin-Padron, J; Farez-Vidal, ME

The value of desmosomal plaque-related markers to distinguish squamous cell carcinoma and adenocarcinoma of the lung

UPSALA JOURNAL OF MEDICAL SCIENCES, 2020;

FI:1,955; Q2

Cuadros, M; Andrades, A; Coira, IF; Balinas, C; Rodriguez, MI; Alvarez-Perez, JC; Peinado, P; Arenas, AM; Garcia, DJ; Jimenez, P; Camos, M; Jimenez-Velasco, A; Medina, PP

Expression of the long non-coding RNA TCL6 is associated with clinical outcome in pediatric B-cell acute lymphoblastic leukemia

BLOOD CANCER JOURNAL, 2019;

FI:7,895; D1

Cuadros, M; Sanchez-Martin, V; Herrera-Merchan, A; Balinas, C; Martin-Padron, J; Boyero, L; Peinado, P; Medina, PP

BRG1 regulation by miR-155 in human leukemia and lymphoma cell lines (vol 19, pg 1010, 2017)

CLINICAL & TRANSLATIONAL ONCOLOGY, 2019;

FI:2,441; Q3

Perea, F; Sanchez-Palencia, A; Gomez-Morales, M; Bernal, M; Concha, A; Garcia, MM; Gonzalez-Ramirez, AR; Kerick, M; Martin, J; Garrido, F; Ruiz-Cabello, F; Aptsiauri, N

HLA class I loss and PD-L1 expression in lung cancer: impact on T-cell infiltration and immune escape

ONCOTARGET, 2018;

Quero-Valenzuela, F; Piedra-Fernandez, I; Martinez-Ceres, M; Romero-Palacios, PJ; Sanchez-Palencia, A; De Guevara, ACL; Torne-Poyatos, P

Predictors for 30-day readmission after pulmonary resection for lung cancer

JOURNAL OF SURGICAL ONCOLOGY, 2018;

FI:2,886; Q1

Perea, F; Bernal, M; Sanchez-Palencia, A; Carretero, J; Torres, C; Bayarri, C; Gomez-Morales, M; Garrido, F; Ruiz-Cabello, F

The absence of HLA class I expression in non-small cell lung cancer correlates with the tumor tissue structure and the pattern of T cell infiltration

INTERNATIONAL JOURNAL OF CANCER, 2017;

FI:6,513; Q1

Conde-Muino, R; Cano, C; Sanchez-Martin, V; Herrera, A; Comino, A; Medina, PP; Palma, P; Cuadros, M

Preoperative chemoradiotherapy for rectal cancer: the sensitizer role of the association between miR-375 and c-Myc

ONCOTARGET, 2017;

FI:5,168; Q1

Gomez-Llorente, MA; Romero, R; Chueca, N; Martinez-Canavate, A; Gomez-Llorente, C

Obesity and Asthma: A Missing Link

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017;

FI:3,226; Q2

Cuadros, M; Sanchez-Martin, V; Herrera, A; Balinas, C; Martin-Padron, J; Boyero, L; Peinado, P; Medina, PP

BRG1 regulation by miR-155 in human leukemia and lymphoma cell lines

CLINICAL & TRANSLATIONAL ONCOLOGY, 2017;

FI:2,353; Q3

Valenzuela, FQ; Fernandez, IP; Cirre, MDM; Sanchez-Palencia, A; de Guevara, ACL

Impact of major video-assisted thoracoscopic surgery on care quality

JOURNAL OF THORACIC DISEASE, 2017;

FI:2,365; Q3

Valenzuela-Membrives, MD; Perea-Garcia, F; Sanchez-Palencia, A; Ruiz-Cabello, F; Gomez-Morales, M; Miranda-Leon, MT; Galindo-Angel, I; Farez-Vida, ME

Progressive changes in composition of lymphocytes in lung tissues from patients with non-small-cell lung cancer

ONCOTARGET, 2016;

FI:5,008; Q1

Verdugo F, Castillo A, Simonian K, Castillo F, Farez-Vidal E, D'Addona A.

Periodontopathogen and Epstein-Barr virus-associated periapical periodontitis may be the source of retrograde infectious peri-implantitis.

CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH, 2015;

FI:3,589; D1

Coira IF, Rufino-Palomares EE, Romero OA, Peinado P, Metheetrairut C, Boyero-Corral L, Carretero J, Farez-Vidal E, Cuadros M, Reyes-Zurita FJ, Lupiáñez JA, Sánchez-Cespedes M, Slack FJ, Medina PP